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  • Currently displaying 21 - 40 of 1100 publications
Liquid-solid coexistence at single fibril resolution during tau condensate ageing
MSR Sahu, J Wei, DA Weitz, TPJ Knowles, K Garai
(2025)
(doi: 10.1101/2025.02.06.636870)
Using a stable protein scaffold to display peptides that bind to alpha-synuclein fibrils
S Bismut, M Schneider, M Miyasaki, Y Feng, E Wilde, D Gunawardena, TPJ Knowles, G Kaminski Schierle, L Itzhaki, J Kumita
(2025)
(doi: 10.1101/2025.02.04.636406)
BPS2025 - Extracellular phase separation mediates storage and release of thyroglobulin in the thyroid follicular lumen
Y Yao, N Erkamp, T Sneideris, X Yang, R Scrutton, MM Schneider, CM Fischer, E Schoenmakers, N Schoenmakers, T Knowles
– Biophysical Journal
(2025)
124,
29a
(doi: 10.1016/j.bpj.2024.11.217)
BPS2025 - Quantifying and predicting antibody non-specificity in the clinical landscape: Microfluidics and machine learning
E de Csillery, H Ausserwöger, M Oeller, I Waibel, R Akbar, A Abrudan, G Krainer, G Invernizzi, P Arosio, N Lorenzen, T Knowles
– Biophysical Journal
(2025)
124,
370a
(doi: 10.1016/j.bpj.2024.11.2003)
BPS2025 - Investigating the role of sequence patterning in the mixing of polymer dense phases
LL Good, TP Knowles, RB Best
– Biophysical Journal
(2025)
124,
78a
(doi: 10.1016/j.bpj.2024.11.486)
BPS2025 - Quantifying and predicting antibody non-specificity in the clinical landscape: Microfluidics and machine learning
E de Csillery, H Ausserwöger, M Oeller, I Waibel, R Akbar, A Abrudan, G Krainer, G Invernizzi, P Arosio, N Lorenzen, T Knowles
– Biophysical Journal
(2025)
124,
57a
(doi: 10.1016/j.bpj.2024.11.377)
BPS2025 - Quantifying temperature-induced changes in protein interactions and phase behavior using high-throughput droplet microfluidics
CM Fischer, H Ausserwöger, T Sneideris, D Qian, R Scrutton, S Qamar, P St George-Hyslop, TP Knowles
– Biophysical Journal
(2025)
124,
79a
(doi: 10.1016/j.bpj.2024.11.488)
BPS2025 - Investigating α-synuclein liquid condensates transition to an irreversible aggregated state
IA Edu, A Levin, T Sneideris, CM Fischer, TPJ Knowles
– Biophysical Journal
(2025)
124,
79a
(doi: 10.1016/j.bpj.2024.11.489)
BPS2025 - Sequence-encoded molecular grammar governs the formation of synaptic condensates
C Hoffmann, K Ruff, IA Edu, MK Shinn, JV Tromm, A Pant, H Ausserwöger, J Morgan, TP Knowles, RV Pappu, D Milovanovic
– Biophysical Journal
(2025)
124,
562a
(doi: 10.1016/j.bpj.2024.11.2925)
BPS2025 - A mathematical model to quantify tau aggregation rates and determine molecular mechanisms from patient data
G Meisl, S-H Huang, A Quaegebeur, T Rittman, M Cotton, J Rowe, TP Knowles, D Klenerman
– Biophysical Journal
(2025)
124,
408a
(doi: 10.1016/j.bpj.2024.11.2197)
BPS2025 - Digital seed amplification quantifies the increase in seeding-competent aggregates in Parkinson's patients' CSF
A Levin, S Cai, H Ausserwoeger, G Meisl, D Qian, R Scrutton, IA Edu, G Krainer, T Sneideris, L Chai, W Arter, TP Knowles
– Biophysical Journal
(2025)
124,
510a
(doi: 10.1016/j.bpj.2024.11.2683)
BPS2025 - Extracellular phase separation mediates the storage and release of thyroglobulin in the thyroid follicular lumen
Y Yao, N Erkamp, T Sneideris, X Yang, R Scrutton, MM Schneider, CM Fischer, E Schoenmakers, N Schoenmakers, T Knowles
– Biophysical Journal
(2025)
124,
566a
(doi: 10.1016/j.bpj.2024.11.2943)
BPS2025 - Single-molecule investigation of liquid-liquid and liquid-solid phase separation of amyloid proteins
M Sahu, J Wei, VK V, TP Knowles, K Garai
– Biophysical Journal
(2025)
124,
411a
(doi: 10.1016/j.bpj.2024.11.2208)
On the reversibility of amyloid fibril formation
T Pálmadóttir, J Getachew, L Ortigosa-Pascual, E Axell, J Wei, U Olsson, TPJ Knowles, S Linse
– Biophys Rev (Melville)
(2025)
6,
011303
(doi: 10.1063/5.0236947)
Competing addition processes give distinct growth regimes in the assembly of 1D filaments.
SA Akram, T Brown, S Whitelam, G Meisl, TPJ Knowles, JD Schmit
– Biophys J
(2025)
124,
778
(doi: 10.1016/j.bpj.2025.01.018)
Lipid-induced condensate formation from the Alzheimer's Aβ peptide triggers amyloid aggregation.
G Šneiderienė, A González Díaz, SD Adhikari, J Wei, T Michaels, T Šneideris, S Linse, M Vendruscolo, K Garai, TPJ Knowles
– Proceedings of the National Academy of Sciences
(2025)
122,
e2401307122
(doi: 10.1073/pnas.2401307122)
SynPull: An advanced method for studying neurodegeneration-related aggregates in synaptosomes using super-resolution microscopy.
S Kedia, E Fertan, Y Wu, YP Zhang, G Meisl, JYL Lam, F K Wiseman, WA McEwan, A Quaegebeur, MG Spillantini, JSH Danial, D Klenerman
– Cell Chemical Biology
(2025)
32,
338
(doi: 10.1016/j.chembiol.2025.01.001)
Transforming an ATP-dependent enzyme into a dissipative, self-assembling system.
Y Li, J Zhu, Z Zhang, J Wei, F Wang, G Meisl, TPJ Knowles, EH Egelman, FA Tezcan
– Nature Chemical Biology
(2025)
1
(doi: 10.1038/s41589-024-01811-1)
Detecting the Undetectable: Advances in Methods for Identifying Small Tau Aggregates in Neurodegenerative Diseases
D Böken, Y Wu, Z Zhang, D Klenerman
– Chembiochem
(2025)
26,
e202400877
(doi: 10.1002/cbic.202400877)
Tandem-repeat proteins introduce tuneable properties to engineered biomolecular condensates
J Kumita, TLC Ng, M Hoare, MJ Maristany, E Wilde, T Sneideris, J Huertas Martin, B Agbetiameh, M Furukawa, J Joseph, T Knowles, R Collepardo Guevara, L Itzhaki
– Chemical Science
(2025)
(doi: 10.1039/d5sc00903k)

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