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700 MHz TXO Cryo/Open-access/Solid-state Spectrometer - 'Arran' - Room B14

This upgraded spectrometer resulted from much hard work by former STO Peter Grice and the NMR team together with Janet Kumita (formerly Principal Research Associate from the Chemistry of Health research groups and now a Group Leader at the Department of Pharmacology - to get grant funding for the work to be carried out. The instrument however remains part of the departmental NMR facility for open-access usage with a DUL room temperature probe or the TXO Cryoprobe for high performance solution state NMR when not required by Melinda Duer and Alex Forse's groups.

Unless indicated the spectrometer will be available for Open Access overnight experiments running between 7pm and 8am, and during the day will be bookable by trained users (some additional training will be required for current users of Glengrant/Auchentoshan).

There are now four probes suitable for use in the spectrometer. The original solution state TXO Cryoprobe which utilised the 1H, 13C and 15N channels available in the refurbished Avance II+ console to offer protein structural determination capability is now repurposed to offer a high sensitivity overnight open-access experiment setup. The second solution state probe is a room temperature dual type which was formerly used when in open-access mode before the cryoplatform was repaired. The other probes are solid state, and thus the cryoplatform is turned off and the TXO Cryoprobe or DUL probe removed for the periods when solid state NMR is in progress. The first, and already delivered probe type is a MASSB-DR-BB/1H-1.3mm DVT.  In plain English, it is a CPMAS H/X-Nucleus DVT high speed double resonance probehead for Standard Bore magnets suitable for solid state NMR using 1.3mm rotors. It offers an X-Channel which is tunable between 31P and 15N by means of capacitor changes with high power 1H decoupling.  It has a temperature range of -30ºC to +70ºC. It can rotate at up to 67KHz, with special Bruker rotors. A MASSB-TR-C/N/H-3.2 DVT probe is also ready for use.  Contact the NMR Facility team if you would like to use any of the probes on the 700 MHz. We welcome trained users of Glengrant and Auchentoshan to complete the additional training/familiarisation to become cryoprobe users on the 700MHz.

Time can be booked on the 700MHz spectrometer by trained users here.

A description of the Open Access experiments available, with some details of sample requirements is available here.

Reference dataset for external reference quantification is available here.



The picture below shows the Avance 700 as it appears at present with our new SampleCase 60 sample changer.

Arran and the new SampleCase

The next picture is a close up view of the sample holder area of the SampleCase 60 sample changer.

SampleCase 60 sample holders

Lastly here is a video of the fantastic operating mechanism of the SampleCase!!

  • Watch the pneumatic operation of our new SampleCase  - once signed into the Streaming Media Service (Raven login required)