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Department of Chemistry

 

Publications

Trodusquemine enhances Aβ
R Limbocker, S Chia, FS Ruggeri, M Perni, R Cascella, GT Heller, G Meisl, B Mannini, J Habchi, TCT Michaels, PK Challa, M Ahn, ST Casford, N Fernando, CK Xu, ND Kloss, SIA Cohen, JR Kumita, C Cecchi, M Zasloff, S Linse, TPJ Knowles, F Chiti, M Vendruscolo, CM Dobson
– Nature communications
(2019)
10,
225
Chemical and mechanistic analysis of photodynamic inhibition of Alzheimer's beta-amyloid aggregation
M Ahn, BI Lee, S Chia, J Habchi, JR Kumita, M Vendruscolo, CM Dobson, CB Park
– Chemical Communications
(2019)
55,
1152
Stabilization and characterization of cytotoxic Aβ40 oligomers isolated from an aggregation reaction in the presence of Zinc ions
B Mannini, J Habchi, S Chia, FS Ruggeri, M Perni, TPJ Knowles, CM Dobson, M Vendruscolo
– ACS chemical neuroscience
(2018)
9,
2959
SAR by kinetics for drug discovery in protein misfolding diseases
S Chia, J Habchi, TCT Michaels, SIA Cohen, S Linse, CM Dobson, TPJ Knowles, M Vendruscolo
– Proc Natl Acad Sci U S A
(2018)
115,
10245
Microfluidic deposition for resolving single-molecule protein architecture and heterogeneity.
FS Ruggeri, J Charmet, T Kartanas, Q Peter, S Chia, J Habchi, CM Dobson, M Vendruscolo, TPJ Knowles
– Nature communications
(2018)
9,
3890
Cholesterol catalyses Aβ42 aggregation through a heterogeneous nucleation pathway in the presence of lipid membranes.
J Habchi, S Chia, C Galvagnion, TCT Michaels, MMJ Bellaiche, FS Ruggeri, M Sanguanini, I Idini, JR Kumita, E Sparr, S Linse, CM Dobson, TPJ Knowles, M Vendruscolo
– Nat Chem
(2018)
10,
673
Chemical Kinetics for Bridging Molecular Mechanisms and Macroscopic Measurements of Amyloid Fibril Formation
TCT Michaels, A Šarić, J Habchi, S Chia, G Meisl, M Vendruscolo, CM Dobson, TPJ Knowles
– Annual review of physical chemistry
(2018)
69,
1
Modulating Amyloid-Beta Aggregation to Reduce the Toxicity of its Oligomeric Aggregates
R Limbocker, B Mannini, S Chia, FS Ruggeri, M Perni, R Cascella, C Xu, J Habchi, JR Kumita, F Chiti, TPJ Knowles, M Vendruscolo, CM Dobson
– Biophysical Journal
(2018)
114,
430a
Systematic Development of Small Molecules to Inhibit Specific Microscopic Steps of Amyloid-Beta42 Aggregation in Alzheimer's Disease
S Chia, J Habchi, R Limbocker, B Mannini, M Ahn, M Perni, O Hansson, P Arosio, JR Kumita, PK Challa, SIA Cohen, S Linse, CM Dobson, TPJ Knowles, M Vendruscolo
– Biophysical Journal
(2018)
114,
225A
Probing the Interaction of ABETA42 Amyloid Species with an Aggregation Suppressor Molecule by Infrared Nanospectroscopy
FS Ruggeri, J Habchi, S Chia, M Vendruscolo, TPJ Knowles
– BIOPHYSICAL JOURNAL
(2018)
114,
224A
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Research Group

Telephone number

01223 763842
01223 763845 (shared)

Email address

skrc2@cam.ac.uk

College

Clare Hall