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Department of Chemistry

 

Publications

Analysis of α-synuclein species enriched from cerebral cortex of humans with sporadic dementia with Lewy bodies
JB Sanderson, S De, H Jiang, M Rovere, M Jin, L Zaccagnini, AH Watson, L De Boni, VN Lagomarsino, TL Young-Pearse, X Liu, TC Pochapsky, BT Hyman, DW Dickson, D Klenerman, DJ Selkoe, T Bartels
– Brain Communications
(2020)
Tracking Oligomerization of Alpha-Synuclein Demonstrates Pivotal Role of Mitochondria in Seeding
ML Choi, MH Horrocks, M Rodrigues, S De, L Tosatto, W Zhang, G Virdi, D Klenerman, AY Abramov, S Gandhi
– BIOPHYSICAL JOURNAL
(2020)
118,
217A
Soluble aggregates present in cerebrospinal fluid change in size and mechanism of toxicity during Alzheimer's disease progression.
S De, DR Whiten, FS Ruggeri, C Hughes, M Rodrigues, DI Sideris, CG Taylor, FA Aprile, S Muyldermans, TPJ Knowles, M Vendruscolo, C Bryant, K Blennow, I Skoog, S Kern, H Zetterberg, D Klenerman
– Acta Neuropathologica Communications
(2019)
7,
120
Different soluble aggregates of A beta 42 can give rise to cellular toxicity through different mechanisms
S De, DC Wirthensohn, P Flagmeier, C Hughes, FA Aprile, FS Ruggeri, DR Whiten, D Emin, Z Xia, JA Varela, P Sormanni, F Kundel, TPJ Knowles, CM Dobson, C Bryant, M Vendruscolo, D Klenerman
– Nature communications
(2019)
10,
1541
Direct observation of prion protein oligomer formation reveals an aggregation mechanism with multiple conformationally distinct species.
JC Sang, J-E Lee, AJ Dear, S De, G Meisl, AM Thackray, R Bujdoso, TPJ Knowles, D Klenerman
– Chemical science
(2019)
10,
4588
Increased Secondary Nucleation Underlies Accelerated Aggregation of the Four-Residue N-Terminally Truncated Aβ42 Species Aβ5-42.
T Weiffert, G Meisl, P Flagmeier, S De, CJR Dunning, B Frohm, H Zetterberg, K Blennow, E Portelius, D Klenerman, CM Dobson, TPJ Knowles, S Linse
– ACS chemical neuroscience
(2019)
10,
2374
Imaging individual protein aggregates to follow aggregation and determine the role of aggregates in neurodegenerative disease
S De, D Klenerman
– BBA - Proteins and Proteomics
(2019)
1867,
870
Mapping Surface Hydrophobicity of alpha-Synuclein Oligomers at the Nanoscale
J-E Lee, JC Sang, M Rodrigues, AR Carr, MH Horrocks, S De, MN Bongiovanni, P Flagmeier, CM Dobson, DJ Wales, SF Lee, D Klenerman
– Nano Letters
(2018)
18,
7494
Quantifying Co-Oligomer Formation by α-Synuclein.
M Iljina, AJ Dear, GA Garcia, S De, L Tosatto, P Flagmeier, DR Whiten, TCT Michaels, D Frenkel, CM Dobson, TPJ Knowles, D Klenerman
– ACS nano
(2018)
12,
10855
¬Nanoscopic characterization of individual endogenous protein aggregates in human neuronal cells
DR Whiten, Y Zuo, L Calo, M-L Choi, S De, P Flagmeier, DC Wirthensohn, F Kundel, RT Ranasinghe, SE Sanchez, D Athauda, SF Lee, CM Dobson, S Gandhi, M-G Spillantini, D Klenerman, MH Horrocks
– Chembiochem : a European journal of chemical biology
(2018)
19,
2033
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Research Group

Telephone number

01223 763965

Email address

23.suman@gmail.com