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Yusuf Hamied Department of Chemistry

 

Publications

Combining experiment and energy landscapes to explore anaerobic heme breakdown in multifunctional hemoproteins.
AD Keith, EB Sawyer, DCY Choy, Y Xie, GS Biggs, OJ Klein, PD Brear, DJ Wales, PD Barker
– Phys Chem Chem Phys
(2024)
26,
695
Sub-single-turnover quantification of enzyme catalysis at ultrahigh throughput via a versatile NAD(P)H coupled assay in microdroplets
M Penner, OJ Klein, M Gantz, S Boss, P Barker, P Dupree, F Hollfelder
(2023)
Ultrahigh-Throughput Directed Evolution of a Metal-Free α/β-Hydrolase with a Cys-His-Asp Triad into an Efficient Phosphotriesterase.
JD Schnettler, OJ Klein, TS Kaminski, P-Y Colin, F Hollfelder
– J Am Chem Soc
(2022)
145,
1083
Ultrahigh-throughput directed evolution of a metal-free α/β-hydrolase with a Cys-His-Asp triad into an efficient phosphotriesterase
D Schnettler Fernández, OJ Klein, T Kaminski, P-Y Colin, F Hollfelder
(2022)
2022.02.14.480337
Controlled Ligand Exchange Between Ruthenium Organometallic Cofactor Precursors and a Naïve Protein Scaffold Generates Artificial Metalloenzymes Catalysing Transfer Hydrogenation
GS Biggs, OJ Klein, SL Maslen, JM Skehel, TJ Rutherford, SMV Freund, F Hollfelder, SR Boss, PD Barker
– Angewandte Chemie
(2021)
133,
11014
Controlled Ligand Exchange Between Ruthenium Organometallic Cofactor Precursors and a Naïve Protein Scaffold Generates Artificial Metalloenzymes Catalysing Transfer Hydrogenation
GS Biggs, OJ Klein, SL Maslen, JM Skehel, TJ Rutherford, SMV Freund, F Hollfelder, SR Boss, PD Barker
– Angew Chem Int Ed Engl
(2021)
60,
10919
Unlocking the Full Evolutionary Potential of Artificial Metalloenzymes Through Direct Metal-Protein Coordination A review of recent advances for catalyst development
GS Biggs, OJ Klein, SR Boss, PD Barker
– Johnson Matthey Technology Review
(2020)
64,
407
Low-temperature mobile phase for peptide trapping at elevated separation temperature prior to nano RP-HPLC-MS/MS
M Schöbinger, OJ Klein, G Mitulović
– Separations
(2016)
3,
6

Research Group

Email address

ojk25@cam.ac.uk