skip to content

Department of Chemistry

 

 

Education

Trinity College, University of Cambridge, UK

PhD Chemistry

Department of Chemistry, University of Cambridge

Project Title: Functionalised Stapled Peptides for Inhibiting Protein-Protein Interactions

  • Designed and synthesised new water-soluble, stable and azide-reactive substituted Sondheimer dialkynes for biocompatible double strain-promoted click chemistry.
  • Demonstrated application of substituted Sondheimer dialkynes in macrocyclization of a p53-based linear peptide to generate functionalised stapled peptides.
  • Applied p53-based functionalised stapled peptides to inhibit the p53-MDM2 interaction as an anti-cancer strategy.
  • Performed detailed experimental and computational (DFT) studies to investigate the reactivity of substituted Sondheimer dialkynes in a double strain-promoted click reaction.

2014-2019

 

St Peter’s College, University of Oxford, UK

MSc (by Research) Organic Chemistry (Commendation Award)

Chemistry Research Laboratory, University of Oxford

Project Title: Diastereo- and Enantioselective Synthesis of Indolines via Chiral-counterion directed Phase-transfer Catalysis

  • Developed a highly diastereo- and enantioselective synthesis of functionalized indolines bearing two contiguous stereocentres, one of which is quaternary and all carbon, in a single synthetic step. Proceeded with complete diastereoselectivity and with high levels of enantioselectivity (up to 99% ee).
  • Performed detailed mechanistic studies which demonstrated the reaction to be an autoinductive phase-transfer initiated process.

2011-2014

 

St. Stephen’s College, University of Delhi, India

BSc (Hons.) Chemistry (Distinction, Aggregate 82%, Rank 3)

2008-2011

 

Research Interests

Organic Chemistry, Asymmetric Synthesis, Organocatalysis, Phase-transfer catalysis, Stapled Peptides, Chemical Biology, Protein-protein interaction inhibition, Click Chemistry, Mechanistic studies.

 

Scholarships and Awards

  • Royal Society of Chemistry early career scientist grant 2019 to participate at 47th IUPAC World Chemistry Congress.
  • American Chemical Society Organic Division Travel Award 2018 to represent at the 255th ACS National Meeting & Exposition, USA.
  • Best Oral Presentation Prize 2018 at the international conference on Emerging Trends in Drugs Development and Natural-Products, India.
  • Trinity College Rouse-Ball and Eddington Research Fund Award 2018 to present PhD research work at the 255th ACS National Meeting & Exposition, USA.
  • Cambridge Philosophical Society Research Studentship Award 2018 to complete an exceptionally promising piece of research.
  • Scholarships awarded in 2014 by Trinity College Cambridge, University of Cambridge Trust and the Jawaharlal Nehru Cambridge Trust to pursue doctoral studies at the University of Cambridge.
  • MSc Thesis Commendation Award 2014, University of Oxford for outstanding work and receiving excellent comments from the examiners at final viva voce examination.
  • Commendation Award 2012, Department of Chemistry, University of Oxford for the high standard of experimental work, written submission and viva voce at the PRS interviews.
  • American Chemical Society Organic Division Travel Award 2013 to represent at the 245th ACS National Meeting & Exposition, USA.
  • Tutor for Graduates Award 2013, St Peter’s College, University of Oxford.
  • J. N. Tata Endowment gift scholarship 2012 for MSc first year research performance.
  • J. N. Tata Endowment scholarship and Sir Ratan Tata travel grant 2011 for graduate studies at University of Oxford.
  • University of Delhi Science Meritorious Award 2010 for standing among the top 20 students in the annual university examinations.
  • Prof. A. C. Jain Merit scholarship 2011, St. Stephen’s College for obtaining the highest marks.
  • Mohan Katyal Memorial Prize 2011, St. Stephen’s College for academic performance, regularity, extra-curricular activities, moral character and selfless service.
  • Special Mention Prize in EUREKA science paper presentation competition, Delhi University.

 

Conference Papers/Posters

  • Sharma, K.; Spring, D. R. (2019): Strain-promoted Stapled Peptides for Inhibiting Protein-protein Interactions”, 47th IUPAC World Chemistry Congress, Paris, France. (Oral)
  • Sharma, K. (2019): “Efficient strained dialkynes for biocompatible double strain-promoted click chemistry”, 6th World Congress on Nanomedical Sciences / Chemical-Biology Interface Synergistic New Frontiers, India. (Oral) 
  • Sharma, K.; Spring, D. R. (2018): “Strain-promoted Double-click Functionalised Stapled Peptides for Inhibiting Protein-protein Interactions”, 255th ACS National Meeting & Exposition, USA. (Oral)
  • Sharma, K.; Spring, D. R. (2018): “Strain-promoted Double-click Functionalised Stapled Peptides for Inhibiting Protein-protein Interactions”, International conference on Emerging Trends in Drugs Development and Natural-Products, India. (Oral)
  • Sharma, K.; Smith, M. D. (2013): “Diastereo- and Enantioselective Synthesis of Functionalized Indolines via Chiral Counterion Catalysis”, 245th ACS National Meeting & Exposition, USA. (Oral)
  • Sharma, K.; Smith, M. D. (2013): “Diastereo- and Enantioselective Synthesis of Functionalized Indolines via Chiral Counterion Catalysis”, AstraZeneca D.Phil. Symposium, University of Oxford. (Oral)
  • Sharma, K.; Stryzhak, O.; Xu, W.; Itzhaki, L.; Spring, D. R. (2017): “Strain-promoted Double-click Functionalised Stapled Peptides for Inhibiting Protein-protein Interactions”, RSC Chemical Biology Symposium. (Poster)
  • Sharma, K.; Stryzhak, O.; Spring, D. R. (2017): “Synthesis of Functionalised Strained Dialkyne Linkers for Metal-free Peptide Stapling”, RSC 25th International Symposium: Synthesis in Organic Chemistry, Oxford. (Poster)
  • Sharma, K.; Smith, M. D. (2013): “Diastereo- and Enantioselective Synthesis of Functionalized Indolines via Chiral Counterion Catalysis”, RSC 23rd International Symposium: Synthesis in Organic Chemistry, Oxford. (Poster)
  • Sharma, K.; Smith, M. D. (2012): “Diastereo- and Enantioselective Synthesis of Functionalized Indolines via Chiral Counterion Catalysis”, Pfizer Neusentis Symposium, University of Oxford. (Poster)

Publications

Water-soluble, stable and azide-reactive strained dialkynes for biocompatible double strain-promoted click chemistry
K Sharma, AV Strizhak, E Fowler, X Wang, W Xu, C Hatt Jensen, Y Wu, HF Sore, YH Lau, M Hyvönen, LS Itzhaki, DR Spring
– Organic & biomolecular chemistry
(2019)
17,
8014

Research Group

Telephone number

01223 336361 (shared)

Email address

ks705@cam.ac.uk