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Department of Chemistry

 

 

Education

Trinity College, University of Cambridge, UK

PhD Chemistry

Department of Chemistry, University of Cambridge

Project Supervisor: Prof. David R. Spring, Professor of Chemistry and Chemical Biology

Project Title: Functionalised Stapled Peptides for Inhibiting Protein-Protein Interactions

  • Designed and synthesised new water-soluble, stable and azide-reactive substituted Sondheimer dialkynes for biocompatible double strain-promoted click chemistry.
  • Demonstrated application of substituted Sondheimer dialkynes in macrocyclization of a p53-based linear peptide to generate functionalised stapled peptides.
  • Applied p53-based functionalised stapled peptides to inhibit the p53-MDM2 interaction as an anti-cancer strategy.
  • Performed detailed experimental and computational (DFT) studies to investigate the reactivity of substituted Sondheimer dialkynes in a double strain-promoted click reaction.

2014-2019

 

St Peter’s College, University of Oxford, UK

MSc (by Research) Organic Chemistry (Commendation Award)

Chemistry Research Laboratory, University of Oxford

Project Supervisor: Prof. Martin D. Smith, Professor of Organic Chemistry and Director, EPSRC Centre for Doctoral Training in Synthesis for Biology and Medicine

Project Title: Diastereo- and Enantioselective Synthesis of Indolines via Chiral-counterion directed Phase-transfer Catalysis

  • Developed a highly diastereo- and enantioselective synthesis of functionalized indolines bearing two contiguous stereocentres, one of which is quaternary and all carbon, in a single synthetic step. Proceeded with complete diastereoselectivity and with high levels of enantioselectivity (up to 99% ee).
  • Performed detailed mechanistic studies which demonstrated the reaction to be an autoinductive phase-transfer initiated process.

2011-2014

 

St. Stephen’s College, University of Delhi, India

BSc (Hons.) Chemistry (Distinction, Aggregate 82%, Rank 3)

2008-2011

Summer Research Project

Department of Chemistry, Indian Institute of Technology, Delhi

Project Supervisor: Prof. Ajai K. Singh

Project Title: Synthesis of a Chalcogenated Schiff Base and its Complex with Palladium

2010

April-June

 

Research Interests

New synthetic methodology, asymmetric synthesis, organocatalysis, phase-transfer catalysis, chemical biology, protein-protein interactions, stapled peptides, computational chemistry, density functional theory calculations.

 

Scholarships and Awards

  • American Chemical Society Organic Division Travel Award 2018 to represent at the 255th ACS National Meeting & Exposition, USA.
  • Best Oral Presentation Prize 2018 at the international conference on Emerging Trends in Drugs Development and Natural-Products, India.
  • Trinity College Rouse-Ball and Eddington Research Fund Award 2018 to present PhD research work at the 255th ACS National Meeting & Exposition, USA.
  • Cambridge Philosophical Society Research Studentship Award 2018 to complete an exceptionally promising piece of research.
  • Scholarships awarded in 2014 by Trinity College Cambridge, University of Cambridge Trust and the Jawaharlal Nehru Cambridge Trust to pursue doctoral studies at the University of Cambridge.
  • MSc Thesis Commendation Award 2014, University of Oxford for outstanding work and receiving excellent comments from the examiners at final viva voce examination.
  • Commendation Award 2012, Department of Chemistry, University of Oxford for the high standard of experimental work, written submission and viva voce at the PRS interviews.
  • American Chemical Society Organic Division Travel Award 2013 to represent at the 245th ACS National Meeting & Exposition, USA.
  • Tutor for Graduates Award 2013, St Peter’s College, University of Oxford.
  • J. N. Tata Endowment gift scholarship 2012 for MSc first year research performance.
  • J. N. Tata Endowment scholarship and Sir Ratan Tata travel grant 2011 for graduate studies at University of Oxford.
  • University of Delhi Science Meritorious Award 2010 for standing among the top 20 students in the annual university examinations.
  • Prof. A. C. Jain Merit scholarship 2011, St. Stephen’s College for obtaining the highest marks.
  • Mohan Katyal Memorial Prize 2011, St. Stephen’s College for academic performance, regularity, extra-curricular activities, moral character and selfless service.
  • Special Mention Prize in EUREKA science paper presentation competition, Delhi University.

 

Publications

  • Sharma, K.; Wolstenhulme, J. R.; Painter, P.; Yeo, D.; Carmona, P.; Johnston, C. P.; Tantillo, D. J.; Smith, M. D. (2015): “Cation-Controlled Enantioselective and Diastereoselective Synthesis of Indolines: An Autoinductive Phase-Transfer Initiated 5-endo-trig Process”, J. Am. Chem. Soc., 137 (41), 13414–13424.
  • Sharma, K.; Kunciw, D. L.; Xu, W.; Wiedmann, M. M.; Wu, Y.; Sore, H. F.; Galloway, W. R. J. D.; Lau, Y. H.; Itzhaki, L. S.; Spring, D. R. (2018): CHAPTER 8 Double-click Stapled Peptides for Inhibiting Protein-Protein Interactions, in Cyclic Peptides: From Bioorganic Synthesis to Applications, The Royal Society of Chemistry. p. 164-187.
  • Kinghton, R. C.; Sharma, K.; Robertson, N.; Spring, D. R.; Wills, M. (2019): "Synthesis and Reactivity of a Bis-Strained Alkyne Derived from 1,1'-Biphenyl-2,2',6,6'-tetrol", ACS Omega, 4(1), 2160-2167. 
  • Strizhak, A. V.; Sharma, K.; Babii, O.; Afonin, S.; Ulrich, A.; Komarov, I. V.; Spring, D. R. (2018): “Highly Reactive Bis-Cyclooctyne-Modified Diarylethene for SPAAC-mediated Cross-Linking”, Org. Biomol. Chem.

Conference Papers/Posters

  • Sharma, K.; Spring, D. R. (2018): “Strain-promoted Double-click Functionalised Stapled Peptides for Inhibiting Protein-protein Interactions”, 255th ACS National Meeting & Exposition, USA. (Oral)
  • Sharma, K.; Spring, D. R. (2018): “Strain-promoted Double-click Functionalised Stapled Peptides for Inhibiting Protein-protein Interactions”, International conference on Emerging Trends in Drugs Development and Natural-Products, India. (Oral)
  • Sharma, K.; Smith, M. D. (2013): “Diastereo- and Enantioselective Synthesis of Functionalized Indolines via Chiral Counterion Catalysis”, 245th ACS National Meeting & Exposition, USA. (Oral)
  • Sharma, K.; Smith, M. D. (2013): “Diastereo- and Enantioselective Synthesis of Functionalized Indolines via Chiral Counterion Catalysis”, AstraZeneca D.Phil. Symposium, University of Oxford. (Oral)
  • Sharma, K.; Stryzhak, O.; Xu, W.; Itzhaki, L.; Spring, D. R. (2017): “Strain-promoted Double-click Functionalised Stapled Peptides for Inhibiting Protein-protein Interactions”, RSC Chemical Biology Symposium. (Poster)
  • Sharma, K.; Stryzhak, O.; Spring, D. R. (2017): “Synthesis of Functionalised Strained Dialkyne Linkers for Metal-free Peptide Stapling”, RSC 25th International Symposium: Synthesis in Organic Chemistry, Oxford. (Poster)
  • Sharma, K.; Smith, M. D. (2013): “Diastereo- and Enantioselective Synthesis of Functionalized Indolines via Chiral Counterion Catalysis”, RSC 23rd International Symposium: Synthesis in Organic Chemistry, Oxford. (Poster)
  • Sharma, K.; Smith, M. D. (2012): “Diastereo- and Enantioselective Synthesis of Functionalized Indolines via Chiral Counterion Catalysis”, Pfizer Neusentis Symposium, University of
    Oxford
    . (Poster)
  • Sharma, K.; Kaushik, N. K. (2008): “Nanoscience and Nanotechnology”, National Conference in Chemistry: Structure, Reaction Dynamics and Spectroscopy, University of Delhi. (Oral)

Publications

Water-soluble, stable and azide-reactive strained dialkynes for biocompatible double strain-promoted click chemistry
K Sharma, AV Strizhak, E Fowler, X Wang, W Xu, C Hatt Jensen, Y Wu, HF Sore, YH Lau, M Hyvönen, LS Itzhaki, DR Spring
– Organic & biomolecular chemistry
(2019)
17,
8014

Research Group

Telephone number

01223 336361 (shared)

Email address

ks705@cam.ac.uk