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Department of Chemistry

 

I received an Honours B.Sc. in Biochemistry from the University of Waterloo (Canada) and completed my Ph.D. at the University of Toronto in the laboratory of Prof. G.A. Woolley, where my work involved investigating reversible photo-control of peptide structure and activity. In 2003, I was awarded a NSERC Postdoctoral Fellowship and joined the research group of Prof. C.M. Dobson in the Dept. of Chemistry, University of Cambridge, during which time I have been a Co-researcher Investigator on a BBRSC Project grant and am now a Senior Research Associate in the Centre for Misfolding Diseases. My research interests focus on studying the mechanisms of protein misfolding in globular proteins (specifically human lysozyme and disease-related variants), on a molecular level. We are also looking at different protein misfolding systems (Aβ1-42 and TDP-43) to probe the cellular mechanisms involved in protein misfolding and how biological molecules such as extracellular chaperones modify and influence these processes.

Publications

Trodusquemine enhances Aβ42 aggregation but suppresses its toxicity by displacing oligomers from cell membranes
R Limbocker, S Chia, FS Ruggeri, M Perni, R Cascella, GT Heller, G Meisl, B Mannini, J Habchi, TCT Michaels, PK Challa, M Ahn, ST Casford, N Fernando, CK Xu, ND Kloss, SIA Cohen, JR Kumita, C Cecchi, M Zasloff, S Linse, TPJ Knowles, F Chiti, M Vendruscolo, CM Dobson
– Nat Commun
(2019)
10,
225
Defining α-synuclein species responsible for Parkinson disease phenotypes in mice
JM Froula, M Castellana-Cruz, NM Anabtawi, JD Camino, SW Chen, DR Thrasher, J Freire, AA Yazdi, S Fleming, CM Dobson, JR Kumita, N Cremades, LA Volpicelli-Daley
– J Biol Chem
(2019)
294,
jbc.RA119.007743
Secondary nucleation and elongation occur at different sites on Alzheimer's amyloid-beta aggregates
T Scheidt, U Łapińska, JR Kumita, DR Whiten, D Klenerman, MR Wilson, SIA Cohen, S Linse, M Vendruscolo, CM Dobson, TPJ Knowles, P Arosio
– Science Advances
(2019)
5,
eaau3112
Fabrication and Characterization of Reconstituted Silk Microgels for the Storage and Release of Small Molecules
X Liu, Z Toprakcioglu, AJ Dear, A Levin, FS Ruggeri, CG Taylor, M Hu, JR Kumita, M Andreasen, CM Dobson, U Shimanovich, TPJ Knowles
– Macromolecular rapid communications
(2019)
40,
e1800898
Chemical and mechanistic analysis of photodynamic inhibition of Alzheimer's beta-amyloid aggregation
M Ahn, BI Lee, S Chia, J Habchi, JR Kumita, M Vendruscolo, CM Dobson, CB Park
– Chem Commun (Camb)
(2019)
55,
1152
Human pregnancy zone protein stabilizes misfolded proteins including preeclampsia- and Alzheimer's-associated amyloid beta peptide.
JH Cater, JR Kumita, R Zeineddine Abdallah, G Zhao, A Bernardo-Gancedo, A Henry, W Winata, M Chi, BSF Grenyer, ML Townsend, M Ranson, CS Buhimschi, DS Charnock-Jones, CM Dobson, MR Wilson, IA Buhimschi, AR Wyatt
– Proceedings of the National Academy of Sciences of the United States of America
(2019)
116,
6101
Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine.
M Perni, P Flagmeier, R Limbocker, R Cascella, FA Aprile, C Galvagnion, GT Heller, G Meisl, SW Chen, JR Kumita, PK Challa, JB Kirkegaard, SIA Cohen, B Mannini, D Barbut, EAA Nollen, C Cecchi, N Cremades, TPJ Knowles, F Chiti, M Zasloff, M Vendruscolo, CM Dobson
– ACS chemical biology
(2018)
13,
2308
Single-Molecule Characterization of the Interactions between Extracellular Chaperones and Toxic alpha-Synuclein Oligomers
DR Whiten, D Cox, MH Horrocks, CG Taylor, S De, P Flagmeier, L Tosatto, JR Kumita, H Ecroyd, CM Dobson, D Klenerman, MR Wilson
– Cell reports
(2018)
23,
3492
Cholesterol catalyses Aβ42 aggregation through a heterogeneous nucleation pathway in the presence of lipid membranes
J Habchi, S Chia, C Galvagnion, TCT Michaels, MMJ Bellaiche, FS Ruggeri, M Sanguanini, I Idini, JR Kumita, E Sparr, S Linse, CM Dobson, TPJ Knowles, M Vendruscolo
– Nature chemistry
(2018)
10,
673
Modulating Amyloid-Beta Aggregation to Reduce the Toxicity of its Oligomeric Aggregates
R Limbocker, B Mannini, S Chia, FS Ruggeri, M Perni, R Cascella, C Xu, J Habchi, JR Kumita, F Chiti, TPJ Knowles, M Vendruscolo, CM Dobson
– Biophysical Journal
(2018)
114,
430a
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Telephone number

01223 761480

Email address

jrk38@cam.ac.uk