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Department of Chemistry

 

Jeannine was born in a little village in the beautiful canton Lucerne, Switzerland. To study Chemistry, she moved to Zurich where she received her BSc in Chemistry in 2010 from the University of Zurich. Before starting her Master studies, Jeannine participated in a research project in the research group of Prof. Heinz Berke, where she improved Rhenium catalysts for hydrogenation reactions. 

In 2010, Jeannine joined the research group of Prof. Gilles Gasser at the University of Zurich, shifting gears from inorganic to bioinorganic chemistry, aiming to prepare first-in-class organometallic anthelmintic drug candidates. She finished her master studies the same year and started her PhD thesis in the Gasser group in January 2012. During her PhD studies she started to feel highly committed to fight parasitic diseases and was trying to find cures for a range of parasitic worm infections that are an immersive threat to livestock and human. Apart from her key contributions to the synthesis and biological evaluation of organometallic-based derivatives of organic anthelmintics, Jeannine was also active in the field of cancer therapy, where she synthesised and evaluated different ruthenium-based photosensitisers (PSs) for cancer photodynamic therapy (PDT). 

After her PhD studies, Jeannine secured a SNSF Early Postdoc.Mobility Fellowship that allowed her to join the research group of Prof. Chris Abell at the University of Cambridge, to further focus on medicinal chemistry. Since 2016, Jeannine is pursuing rational drug discovery using fragment-based approaches. Recently, she obtained further funding in the form of a MSCA Individual Fellowship to continue the initiated projects and focus on the development of alternative antimicrobial agents.

Publications

Structural insights into Escherichia coli phosphopantothenoylcysteine synthetase by native ion mobility–mass spectrometry
DS-H Chan, J Hess, E Shaw, C Spry, R Starley, C Dagostin, MVB Dias, R Kale, V Mendes, TL Blundell, AG Coyne, C Abell
– Biochem J
(2019)
476,
3125
Assessment of tegumental damage to Schistosoma mansoni and S. haematobium after in vitro exposure to ferrocenyl, ruthenocenyl and benzyl derivatives of oxamniquine using scanning electron microscopy.
V Buchter, J Hess, G Gasser, J Keiser
– Parasites and Vectors
(2018)
11,
580
ATR-Mediated Global Fork Slowing and Reversal Assist Fork Traverse and Prevent Chromosomal Breakage at DNA Interstrand Cross-Links
K Mutreja, J Krietsch, J Hess, S Ursich, M Berti, FK Roessler, R Zellweger, M Patra, G Gasser, M Lopes
– Cell Reports
(2018)
24,
2629
Synthesis, characterization and biological activity of organometallic derivatives of the antimalarial drug mefloquine as new antischistosomal drug candidates
F d'Orchymont, J Hess, G Panic, M Jakubaszek, L Gemperle, J Keiser, G Gasser
– Medchemcomm
(2018)
9,
1905
Ferrocenyl, Ruthenocenyl, and Benzyl Oxamniquine Derivatives with Cross-Species Activity against Schistosoma mansoni and Schistosoma haematobium.
J Hess, G Panic, M Patra, L Mastrobuoni, B Spingler, S Roy, J Keiser, G Gasser
– ACS Infect Dis
(2017)
3,
645
Evaluation of the Medicinal Potential of Two Ruthenium(II) Polypyridine Complexes as One‐ and Two‐Photon Photodynamic Therapy Photosensitizers
J Hess, H Huang, A Kaiser, V Pierroz, O Blacque, H Chao, G Gasser
– Chemistry - A European Journal
(2017)
23,
9888
Synthesis, Characterization, and Biological Activity of Ferrocenyl Analogues of the Anthelmintic Drug Monepantel
J Hess, M Patra, V Pierroz, B Spingler, A Jabbar, S Ferrari, RB Gasser, G Gasser
– Organometallics
(2016)
35,
3369
Bimodal X-ray and Infrared Imaging of an Organometallic Derivative of Praziquantel in Schistosoma mansoni
S Clède, N Cowan, F Lambert, HC Bertrand, R Rubbiani, M Patra, J Hess, C Sandt, N Trcera, G Gasser, J Keiser, C Policar
– Chembiochem
(2016)
17,
1004
Organometallic Derivatization of the Nematocidal Drug Monepantel Leads to Promising Antiparasitic Drug Candidates
J Hess, M Patra, L Rangasamy, S Konatschnig, O Blacque, A Jabbar, P Mac, EM Jorgensen, RB Gasser, G Gasser
– Chemistry - A European Journal
(2016)
22,
16602
Assessment of the nematocidal activity of metallocenyl analogues of monepantel
J Hess, M Patra, A Jabbar, V Pierroz, S Konatschnig, B Spingler, S Ferrari, RB Gasser, G Gasser
– Dalton Trans
(2016)
45,
17662
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Research Group

Telephone number

01223 330190 (shared)

Email address

jh2083@cam.ac.uk