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Yusuf Hamied Department of Chemistry

 

Dr Hongbin Yang was awarded the second junior CAMS fellowship in 2019. Hongbin started his post-doctoral research project focussed on computational toxicology in November under the academic mentorship of CAMS steering committee member Dr Andreas Bender. Hongbin will have access to the industry knowledge and resources of both AstraZeneca and GSK. 

After completing a BSc at East China University of Science and Technology (ECUST) in Shanghai, Hongbin continued his studies here and was awarded a PhD entitled; In Silico Prediction of Chemical ADMET Properties via Statistics and Machine Learning Methods, during which Hongbin focused on structural alerts and QSAR techniques for toxicity prediction and toxicology research. After graduation, Hongbin had a short-term internship in WuXi AppTec (Shanghai), where he combined cheminformatics and deep learning techniques to design retro-synthesis plans.

Publications

Comparison of Cellular Morphological Descriptors and Molecular Fingerprints for the Prediction of Cytotoxicity- and Proliferation-Related Assays.
S Seal, H Yang, L Vollmers, A Bender
– Chemical Research in Toxicology
(2021)
34,
422
Prediction and mechanistic analysis of drug-induced liver injury (DILI) based on chemical structure
A Liu, M Walter, P Wright, A Bartosik, D Dolciami, A Elbasir, H Yang, A Bender
– Biology direct
(2021)
16,
6
Insights into the synergistic mechanism of target resistance: A case study of N. lugens RDL-GABA receptors and fipronil.
T Li, C Zhou, N Zheng, H Yang, G Kuang, X Shao, Z Li, J Cheng
– Biophys Chem
(2020)
265,
106426
Computational Approaches to Identify Structural Alerts and Their Applications in Environmental Toxicology and Drug Discovery
H Yang, C Lou, W Li, G Liu, Y Tang
– Chem Res Toxicol
(2020)
33,
1312
In Silico Prediction of Human Renal Clearance of Compounds Using Quantitative Structure-Pharmacokinetic Relationship Models.
J Chen, H Yang, L Zhu, Z Wu, W Li, Y Tang, G Liu
– Chemical research in toxicology
(2020)
33,
640
Prediction of the allergic mechanism of haptens via a reaction-substructure-compound-target-pathway network system
P Di, Z Wu, H Yang, W Li, Y Tang, G Liu
– Toxicology letters
(2019)
317,
68
Insights into mechanisms and severity of drug-induced liver injury via computational systems toxicology approach
Y Peng, Z Wu, H Yang, Y Cai, G Liu, W Li, Y Tang
– Toxicology letters
(2019)
312,
22
Insights into pesticide toxicity against aquatic organism: QSTR models on Daphnia Magna.
L He, K Xiao, C Zhou, G Li, H Yang, Z Li, J Cheng
– Ecotoxicology and environmental safety
(2019)
173,
285
In Silico Prediction of Endocrine Disrupting Chemicals Using Single-Label and Multilabel Models.
L Sun, H Yang, Y Cai, W Li, G Liu, Y Tang
– Journal of chemical information and modeling
(2019)
59,
973
In silico prediction of chemical reproductive toxicity using machine learning.
C Jiang, H Yang, P Di, W Li, Y Tang, G Liu
– Journal of applied toxicology : JAT
(2019)
39,
844
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Research Group

Email address

hy353@cam.ac.uk