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Department of Chemistry

 

Publications

Functionalized Double Strain-Promoted Stapled Peptides for Inhibiting the p53-MDM2 Interaction.
K Sharma, AV Strizhak, E Fowler, W Xu, B Chappell, HF Sore, WRJD Galloway, MN Grayson, YH Lau, LS Itzhaki, DR Spring
– ACS Omega
(2020)
5,
1157
Direct Synthesis of N -Functionalized Dipropargylamine Linkers as Models for Use in Peptide Stapling
A Renzetti, RN Rutherford, K Fukumoto, D Kunciw, HF Sore, DR Spring
– Synlett
(2019)
30,
2153
Water-soluble, stable and azide-reactive strained dialkynes for biocompatible double strain-promoted click chemistry
K Sharma, AV Strizhak, E Fowler, X Wang, W Xu, C Hatt Jensen, Y Wu, HF Sore, YH Lau, M Hyvönen, LS Itzhaki, DR Spring
– Organic & biomolecular chemistry
(2019)
17,
8014
Macrocyclisation and functionalisation of unprotected peptides via divinyltriazine cysteine stapling
NS Robertson, SJ Walsh, E Fowler, M Yoshida, SM Rowe, Y Wu, HF Sore, JS Parker, DR Spring
– Chemical communications (Cambridge, England)
(2019)
55,
9499
Strategies for the Diversity-Oriented Synthesis of Macrocycles
KT Mortensen, TJ Osberger, TA King, HF Sore, DR Spring
– Chem Rev
(2019)
119,
10288
Spirocycles as Rigidified sp3-Rich Scaffolds for a Fragment Collection
A Sveiczer, AJP North, N Mateu, SL Kidd, HF Sore, DR Spring
– Organic Letters
(2019)
21,
4600
Efficient development of stable and highly functionalised peptides targeting the CK2 alpha/CK2 beta protein-protein interaction
J Iegre, P Brear, DJ Baker, YS Tan, EL Atkinson, HF Sore, DH O' Donovan, CS Verma, M Hyvönen, DR Spring
– Chemical Science
(2019)
10,
5056
Toolbox of Diverse Linkers for Navigating the Cellular Efficacy Landscape of Stapled Peptides
Y Wu, A Kaur, E Fowler, MM Wiedmann, R Young, WRJD Galloway, L Olsen, HF Sore, A Chattopadhyay, TT-L Kwan, W Xu, SJ Walsh, P de Andrade, M Janecek, S Arumugam, LS Itzhaki, YH Lau, DR Spring
– ACS chemical biology
(2019)
14,
526
A general approach for the site-selective modification of native proteins, enabling the generation of stable and functional antibody-drug conjugates (vol 10, 2019)
SJ Walsh, S Omarjee, WRJD Galloway, TT-L Kwan, HF Sore, JS Parker, M Hyvönen, JS Carroll, DR Spring
– Chem Sci
(2019)
10,
633
Targeted covalent inhibitors of MDM2 using electrophile-bearing stapled peptides.
J Charoenpattarapreeda, YS Tan, J Iegre, SJ Walsh, E Fowler, RS Eapen, Y Wu, HF Sore, CS Verma, L Itzhaki, DR Spring
– Chemical communications (Cambridge, England)
(2019)
55,
7914
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Research Group

Telephone number

01223 763150 (shared)
01223 763929 (shared)
36361 (shared)

Email address

hfs27@cam.ac.uk