Dimitrios Sideris

BBSRC CASE Industrial PhD Studentship with AstraZeneca

Project: Protein Aggregation in Ageing

Preclinical testing of passive immunotherapies against amyloid-beta 1-42, a protein strongly implicated with Alzheimer's disease.

Publications

Soluble amyloid beta-containing aggregates are present throughout the brain at early stages of Alzheimer's disease.

DI Sideris, JSH Danial, D Emin, FS Ruggeri, Z Xia, YP Zhang, E Lobanova, H Dakin, S De, A Miller, JC Sang, TPJ Knowles, M Vendruscolo, G Fraser, D Crowther, D Klenerman

– Brain communications

(2021)

fcab147

(DOI: 10.1093/braincomms/fcab147)

Soluble aggregates present in cerebrospinal fluid change in size and mechanism of toxicity during Alzheimer's disease progression

S De, DR Whiten, FS Ruggeri, C Hughes, M Rodrigues, DI Sideris, CG Taylor, FA Aprile, S Muyldermans, TPJ Knowles, M Vendruscolo, C Bryant, K Blennow, I Skoog, S Kern, H Zetterberg, D Klenerman

– Acta neuropathologica communications

(2019)

120

(DOI: 10.1186/s40478-019-0777-4)

Synapse loss in the prefrontal cortex is associated with cognitive decline in amyotrophic lateral sclerosis.

CM Henstridge, DI Sideris, E Carroll, S Rotariu, S Salomonsson, M Tzioras, C-A McKenzie, C Smith, CAF von Arnim, AC Ludolph, D Lulé, D Leighton, J Warner, E Cleary, J Newton, R Swingler, S Chandran, TH Gillingwater, S Abrahams, TL Spires-Jones

– Acta Neuropathol

(2017)

135,

213

(DOI: 10.1007/s00401-017-1797-4)

Yusuf Hamied Department of Chemistry

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