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Yusuf Hamied Department of Chemistry


BBSRC CASE Industrial PhD Studentship with AstraZeneca

Project: Protein Aggregation in Ageing

Preclinical testing of passive immunotherapies against amyloid-beta 1-42, a protein strongly implicated with Alzheimer's disease.


Soluble amyloid beta-containing aggregates are present throughout the brain at early stages of Alzheimer's disease.
DI Sideris, JSH Danial, D Emin, FS Ruggeri, Z Xia, YP Zhang, E Lobanova, H Dakin, S De, A Miller, JC Sang, TPJ Knowles, M Vendruscolo, G Fraser, D Crowther, D Klenerman
– Brain communications
Soluble aggregates present in cerebrospinal fluid change in size and mechanism of toxicity during Alzheimer's disease progression
S De, DR Whiten, FS Ruggeri, C Hughes, M Rodrigues, DI Sideris, CG Taylor, FA Aprile, S Muyldermans, TPJ Knowles, M Vendruscolo, C Bryant, K Blennow, I Skoog, S Kern, H Zetterberg, D Klenerman
– Acta neuropathologica communications
Synapse loss in the prefrontal cortex is associated with cognitive decline in amyotrophic lateral sclerosis.
CM Henstridge, DI Sideris, E Carroll, S Rotariu, S Salomonsson, M Tzioras, C-A McKenzie, C Smith, CAF von Arnim, AC Ludolph, D Lulé, D Leighton, J Warner, E Cleary, J Newton, R Swingler, S Chandran, TH Gillingwater, S Abrahams, TL Spires-Jones
– Acta Neuropathol

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