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Department of Chemistry

 

Publications

Nanoscopic Characterisation of Individual Endogenous Protein Aggregates in Human Neuronal Cells
DR Whiten, Y Zuo, L Calo, M-L Choi, S De, P Flagmeier, DC Wirthensohn, F Kundel, RT Ranasinghe, SE Sanchez, D Athauda, SF Lee, CM Dobson, S Gandhi, M-G Spillantini, D Klenerman, MH Horrocks
– ChemBioChem
(2018)
19,
2033
Shedding light on aberrant interactions - a review of modern tools for studying protein aggregates.
F Kundel, L Tosatto, DR Whiten, DC Wirthensohn, MH Horrocks, D Klenerman
– The FEBS journal
(2018)
285,
3604
Inhibiting the Ca2+ influx induced by human CSF
A Drews, S De, P Flagmeier, DC Wirthensohn, W-H Chen, DR Whiten, M Rodrigues, C Vincke, S Muyldermans, RW Paterson, CF Slattery, NC Fox, JM Schott, H Zetterberg, CM Dobson, S Gandhi, D Klenerman
– Cell reports
(2017)
21,
3310
The human CTF4-orthologue AND-1 interacts with DNA polymerase α/primase via its unique C-terminal HMG box.
ML Kilkenny, AC Simon, J Mainwaring, D Wirthensohn, S Holzer, L Pellegrini
– Journal of the Royal Society Interface
(2017)
14,
170217
Ultrasensitive Measurement of Ca 2+ Influx into Lipid Vesicles Induced by Protein Aggregates
P Flagmeier, S De, DC Wirthensohn, SF Lee, C Vincke, S Muyldermans, TPJ Knowles, S Gandhi, CM Dobson, D Klenerman
– Angewandte Chemie International Edition
(2017)
56,
7750
Ultrasensitive Measurement of Ca2+ Influx into Lipid Vesicles Induced by Protein Aggregates
P Flagmeier, S De, DC Wirthensohn, SF Lee, C Vincke, S Muyldermans, TPJ Knowles, S Gandhi, CM Dobson, D Klenerman
– Angewandte Chemie
(2017)
129,
7858
Multi-dimensional super-resolution imaging enables surface hydrophobicity mapping.
MN Bongiovanni, J Godet, MH Horrocks, L Tosatto, AR Carr, DC Wirthensohn, RT Ranasinghe, J-E Lee, A Ponjavic, JV Fritz, CM Dobson, D Klenerman, SF Lee
– Nature communications
(2016)
7,
13544
Individual aggregates of amyloid beta induce temporary calcium influx through the cell membrane of neuronal cells
A Drews, J Flint, N Shivji, P Jönsson, D Wirthensohn, E De Genst, C Vincke, S Muyldermans, C Dobson, D Klenerman
– Scientific Reports
(2016)
6,
31910
Ctf4 Is a Hub in the Eukaryotic Replisome that Links Multiple CIP-Box Proteins to the CMG Helicase.
F Villa, AC Simon, MA Ortiz Bazan, ML Kilkenny, D Wirthensohn, M Wightman, D Matak-Vinkovíc, L Pellegrini, K Labib
– Molecular Cell
(2016)
63,
385

Research Group

Telephone number

01223 336421 (shared)

Email address

dcw37@cam.ac.uk