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Department of Chemistry

 

My main research interests lie at the interface of experimental and theoretical techniques to obtain atomic-resolution understanding of the structure and dynamics of nucleo-protein complexes. During my Ph. D., I studied the dynamics of the HIV-1 TAR RNA using NMR spectroscopy data in combination with molecular dynamics simulations. For my postdoctoral research, I have now taken up the long-standing challenge of determining the structure of the whole HIV-1 ribonucleoprotein transactivation complex (TAC) by X-ray crystallography. 

Publications

Simultaneous NMR characterisation of multiple minima in the free energy landscape of an RNA UUCG tetraloop.
AN Borkar, P Vallurupalli, C Camilloni, LE Kay, M Vendruscolo
– Physical Chemistry Chemical Physics
(2017)
19,
2797
Structure of a low-population binding intermediate in protein-RNA recognition.
AN Borkar, MF Bardaro, C Camilloni, FA Aprile, G Varani, M Vendruscolo
– Proc Natl Acad Sci U S A
(2016)
113,
7171
86 Fast click-slow release strategy towards HPLC-free synthesis of RNA strands
AN Borkar, P Vallurupalli, C Camilloni, LE Kay, M Vendruscolo
– Journal of Biomolecular Structure and Dynamics
(2015)
33,
58
A method of determining RNA conformational ensembles using structure-based calculations of residual dipolar couplings.
AN Borkar, A De Simone, RW Montalvao, M Vendruscolo
– The Journal of chemical physics
(2013)
138,
215103
Facile backbone (1H, 15N, 13Ca, and 13C′) assignment of 13C/15N-labeled proteins using orthogonal projection planes of HNN and HN(C)N experiments and its automation
D Kumar, A Borkar, RV Hosur
– Magn Reson Chem
(2012)
50,
357
Denaturation of HIV-1 Protease (PR) Monomer by Acetic Acid: Mechanistic and Trajectory Insights from Molecular Dynamics Simulations and NMR
A Borkar, MK Rout, RV Hosur
– J Biomol Struct Dyn
(2012)
29,
893
AUTOBA: Automation of backbone assignment from HN(C)N suite of experiments
A Borkar, D Kumar, RV Hosur
– J Biomol NMR
(2011)
50,
285
Visualization of early events in acetic acid denaturation of HIV-1 protease: a molecular dynamics study.
AN Borkar, MK Rout, RV Hosur
– PLoS ONE
(2011)
6,
e19830
Structure and Dynamics of Double Helical DNA in Torsion Angle Hyperspace: A Molecular Mechanics Approach
A Borkar, I Ghosh, D Bhattacharyya
– J Biomol Struct Dyn
(2010)
27,
695

Research Group

Telephone number

01223 763842
01223 763845 (shared)

Email address

anb39@cam.ac.uk