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Dr Anthony Coyne

I received my B.Sc (Hons) from the National University of Ireland, Galway (1998) and my Ph.D (2002) from the same university under the direction of Prof. Richard Butler. My Ph.D work focused on the synthetic and mechanistic aspects of the Huisgen cycloaddition reaction with an emphasis on the role of water as a reaction solvent. I then moved to an industrial position with GlaxoSmithKline and returned to academia as a postdoctoral fellow (2004) to the group of Prof Pat Guiry at University College Dublin. In 2006 I moved to a postdoctoral position at the University of Cambridge in the group of Dr Martin Smith. In 2008 I moved to my current position in the group of Prof. Chris Abell at the University of Cambridge where I am a Senior Research Associate. I currently co-supervise the Abell research group.




Mass spectrometry for fragment screening
DS-H Chan, AJ Whitehouse, AG Coyne, C Abell
– Essays Biochem
Effect of DMSO on Protein Structure and Interactions Assessed by Collision-Induced Dissociation and Unfolding.
DS-H Chan, ME Kavanagh, KJ McLean, AW Munro, D Matak-Vinković, AG Coyne, C Abell
– Anal Chem
Allosteric Targeting of Aurora A Kinase Using Small Molecules: A Step Forward Towards Next Generation Medicines?
RC Panicker, AG Coyne, R Srinivasan
– Current medicinal chemistry
Fragment Screening against the EthR–DNA Interaction by Native Mass Spectrometry
DS-H Chan, V Mendes, SE Thomas, BN McConnell, D Matak-Vinković, AG Coyne, TL Blundell, C Abell
– Angew Chem Int Ed Engl
Structural insights into the EthR–DNA interaction using native mass spectrometry
D Shiu-Hin Chan, W-G Seetoh, BN McConnell, D Matak-Vinković, SE Thomas, V Mendes, M Blaszczyk, AG Coyne, TL Blundell, C Abell
– Chemical communications (Cambridge, England)
Fragment Profiling Approach to Inhibitors of the Orphan M. tuberculosis P450 CYP144A1
ME Kavanagh, J Chenge, A Zoufir, KJ McLean, AG Coyne, A Bender, AW Munro, C Abell
– Biochemistry
Structural Characterization and Ligand/Inhibitor Identification Provide Functional Insights into the Mycobacterium tuberculosis Cytochrome P450 CYP126A1.
JT Chenge, LV Duyet, S Swami, KJ McLean, ME Kavanagh, AG Coyne, SEJ Rigby, MR Cheesman, HM Girvan, CW Levy, B Rupp, JP von Kries, C Abell, D Leys, AW Munro
– J Biol Chem
Corrigendum: Substrate Fragmentation for the Design of M. tuberculosis CYP121 Inhibitors.
ME Kavanagh, JL Gray, SH Gilbert, AG Coyne, KJ McLean, HJ Davis, AW Munro, C Abell
– ChemMedChem
Organic synthesis reactions on-water at the organic-liquid water interface.
RN Butler, AG Coyne
– Org Biomol Chem
Fragment-based approaches to TB drugs
C Marchetti, DSH Chan, AG Coyne, C Abell
– Parasitology
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01223 336055

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