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Dr Anthony Coyne

I received my B.Sc (Hons) from the National University of Ireland, Galway (1998) and my Ph.D (2002) from the same university under the direction of Prof. Richard Butler. My Ph.D work focused on the synthetic and mechanistic aspects of the Huisgen cycloaddition reaction with an emphasis on the role of water as a reaction solvent. I then moved to an industrial position with GlaxoSmithKline and returned to academia as a postdoctoral fellow (2004) to the group of Prof Pat Guiry at University College Dublin. In 2006 I moved to a postdoctoral position at the University of Cambridge in the group of Dr Martin Smith. In 2008 I moved to my current position in the group of Prof. Chris Abell at the University of Cambridge where I am a Senior Research Associate. I currently co-supervise the Abell research group.

 

 

Publications

Mass spectrometry for fragment screening
DS-H Chan, AJ Whitehouse, AG Coyne, C Abell
– Essays Biochem
(2017)
61,
465
Effect of DMSO on Protein Structure and Interactions Assessed by Collision-Induced Dissociation and Unfolding.
DS-H Chan, ME Kavanagh, KJ McLean, AW Munro, D Matak-Vinković, AG Coyne, C Abell
– Anal Chem
(2017)
89,
9976
Allosteric Targeting of Aurora A Kinase Using Small Molecules: A Step Forward Towards Next Generation Medicines?
RC Panicker, AG Coyne, R Srinivasan
– Current medicinal chemistry
(2017)
24,
Fragment Screening against the EthR–DNA Interaction by Native Mass Spectrometry
DS-H Chan, V Mendes, SE Thomas, BN McConnell, D Matak-Vinković, AG Coyne, TL Blundell, C Abell
– Angew Chem Int Ed Engl
(2017)
56,
7488
Structural insights into the EthR–DNA interaction using native mass spectrometry
D Shiu-Hin Chan, W-G Seetoh, BN McConnell, D Matak-Vinković, SE Thomas, V Mendes, M Blaszczyk, AG Coyne, TL Blundell, C Abell
– Chemical communications (Cambridge, England)
(2017)
53,
3527
Fragment Profiling Approach to Inhibitors of the Orphan M. tuberculosis P450 CYP144A1
ME Kavanagh, J Chenge, A Zoufir, KJ McLean, AG Coyne, A Bender, AW Munro, C Abell
– Biochemistry
(2017)
56,
1559
Structural Characterization and Ligand/Inhibitor Identification Provide Functional Insights into the Mycobacterium tuberculosis Cytochrome P450 CYP126A1.
JT Chenge, LV Duyet, S Swami, KJ McLean, ME Kavanagh, AG Coyne, SEJ Rigby, MR Cheesman, HM Girvan, CW Levy, B Rupp, JP von Kries, C Abell, D Leys, AW Munro
– J Biol Chem
(2017)
292,
1310
Corrigendum: Substrate Fragmentation for the Design of M. tuberculosis CYP121 Inhibitors.
ME Kavanagh, JL Gray, SH Gilbert, AG Coyne, KJ McLean, HJ Davis, AW Munro, C Abell
– ChemMedChem
(2017)
12,
194
Organic synthesis reactions on-water at the organic-liquid water interface.
RN Butler, AG Coyne
– Org Biomol Chem
(2016)
14,
9945
Fragment-based approaches to TB drugs
C Marchetti, DSH Chan, AG Coyne, C Abell
– Parasitology
(2016)
145,
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Research Group

Telephone number

01223 336055

Email address

agc40@cam.ac.uk