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Department of Chemistry

 

 

 

Publications

Using a Fragment-Based Approach to Identify Alternative Chemical Scaffolds Targeting Dihydrofolate Reductase from Mycobacterium tuberculosis.
JA Ribeiro, A Hammer, GA Libreros-Zúñiga, SM Chavez-Pacheco, P Tyrakis, GS de Oliveira, T Kirkman, J El Bakali, SA Rocco, ML Sforça, R Parise-Filho, AG Coyne, TL Blundell, C Abell, MVB Dias
– ACS Infect Dis
(2020)
6,
2192
Fragment-based discovery of a new class of inhibitors targeting mycobacterial tRNA modification
SE Thomas, AJ Whitehouse, K Brown, S Burbaud, JM Belardinelli, J Sangen, R Lahiri, MDJ Libardo, P Gupta, S Malhotra, HIM Boshoff, M Jackson, C Abell, AG Coyne, TL Blundell, RA Floto, V Mendes
– Nucleic Acids Res
(2020)
48,
8099
Fragment-based design of mycobacterium tuberculosis inha inhibitors
M Sabbah, V Mendes, RG Vistal, DMG Dias, M Záhorszká, K Mikušová, J Korduláková, AG Coyne, TL Blundell, C Abell
– Journal of Medicinal Chemistry
(2020)
63,
4749
Covalent inactivation of Mycobacterium thermoresistibile inosine-5′-monophosphate dehydrogenase (IMPDH)
A Trapero, A Pacitto, DS-H Chan, C Abell, TL Blundell, DB Ascher, AG Coyne
– Bioorganic & Medicinal Chemistry Letters
(2020)
30,
126792
Allosteric Small-Molecule Serine/Threonine Kinase Inhibitors.
RC Panicker, S Chattopadhaya, AG Coyne, R Srinivasan
– Adv Exp Med Biol
(2019)
1163,
253
Targeting of fumarate hydratase from Mycobacterium tuberculosis using allosteric inhibitors with a dimeric-binding mode
AJ Whitehouse, MDJ Libardo, M Kasbekar, PD Brear, G Fischer, CJ Thomas, CE Barry, HIM Boshoff, AG Coyne, C Abell
– J Med Chem
(2019)
62,
10586
Structural insights into Escherichia coli phosphopantothenoylcysteine synthetase by native ion mobility-mass spectrometry.
DS-H Chan, J Hess, E Shaw, C Spry, R Starley, C Dagostin, MVB Dias, R Kale, V Mendes, TL Blundell, AG Coyne, C Abell
– Biochemical Journal
(2019)
476,
3125
Development of inhibitors against mycobacterium abscessus tRNA (m1G37) Methyltransferase (TrmD) Using Fragment-Based Approaches
AJ Whitehouse, SE Thomas, KP Brown, A Fanourakis, DS-H Chan, MDJ Libardo, V Mendes, HIM Boshoff, RA Floto, C Abell, TL Blundell, AG Coyne
– Journal of medicinal chemistry
(2019)
62,
7210
Structure-guided Fragment-based Drug Discovery at the Synchrotron: Screening Binding Sites and Correlations with Hotspot Mapping
SE Thomas, P Collins, RH James, V Mendes, S Charoensutthivarakul, C Radoux, C Abell, AG Coyne, RA Floto, F von Delft, TL Blundell
– Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences
(2019)
377,
20180422
meta‐Nitration of Arenes Bearing ortho/para Directing Group(s) Using C−H Borylation
X Li, X Deng, AG Coyne, R Srinivasan
– Chemistry - A European Journal
(2019)
25,
8018
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Research Group

Telephone number

01223 336055

Email address

agc40@cam.ac.uk