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Dr Anthony Coyne

I received my B.Sc (Hons) from the National University of Ireland, Galway (1998) and my Ph.D (2002) from the same university under the direction of Prof. Richard Butler. My Ph.D work focused on the synthetic and mechanistic aspects of the Huisgen cycloaddition reaction with an emphasis on the role of water as a reaction solvent. I then moved to an industrial position with GlaxoSmithKline and returned to academia as a postdoctoral fellow (2004) to the group of Prof Pat Guiry at University College Dublin. In 2006 I moved to a postdoctoral position at the University of Cambridge in the group of Dr Martin Smith. In 2008 I moved to my current position in the group of Prof. Chris Abell at the University of Cambridge where I am a Senior Research Associate. I currently co-supervise the Abell research group.

 

 

Publications

Mass spectrometry for fragment screening.
DS-H Chan, AJ Whitehouse, AG Coyne, C Abell
– Essays Biochem
(2017)
Allosteric Targeting of Aurora A Kinase Using Small Molecules: A Step Forward Towards Next Generation Medicines?
RC Panicker, AG Coyne, R Srinivasan
– Current medicinal chemistry
(2017)
24,
Structural Characterization and Ligand/Inhibitor Identification Provide Functional Insights into the Mycobacterium tuberculosis Cytochrome P450 CYP126A1.
JT Chenge, LV Duyet, S Swami, KJ McLean, ME Kavanagh, AG Coyne, SEJ Rigby, MR Cheesman, HM Girvan, CW Levy, B Rupp, JP von Kries, C Abell, D Leys, AW Munro
– J Biol Chem
(2017)
292,
1310
Fragment Profiling Approach to Inhibitors of the Orphan M. tuberculosis P450 CYP144A1
ME Kavanagh, J Chenge, A Zoufir, KJ McLean, AG Coyne, A Bender, AW Munro, C Abell
– Biochemistry
(2017)
56,
1559
Corrigendum: Substrate Fragmentation for the Design of M. tuberculosis CYP121 Inhibitors.
ME Kavanagh, JL Gray, SH Gilbert, AG Coyne, KJ McLean, HJ Davis, AW Munro, C Abell
– ChemMedChem
(2017)
12,
194
Organic synthesis reactions on-water at the organic-liquid water interface.
RN Butler, AG Coyne
– Org Biomol Chem
(2016)
14,
9945
Fragment-based approaches to TB drugs
C Marchetti, DSH Chan, AG Coyne, C Abell
– Parasitology
(2016)
1
Insight into Protein Conformation and Subcharging by DMSO from Native Ion Mobility Mass Spectrometry
DS-H Chan, D Matak-Vinkovic, AG Coyne, C Abell
– ChemistrySelect
(2016)
1,
5686
Substrate Fragmentation for the Design of M. tuberculosis CYP121 Inhibitors.
ME Kavanagh, JL Gray, SH Gilbert, AG Coyne, KJ McLean, HJ Davis, AW Munro, C Abell
– ChemMedChem
(2016)
11,
1924
Spirooxindoles as novel 3D-fragment scaffolds: Synthesis and screening against CYP121 from M. tuberculosis.
HJ Davis, ME Kavanagh, T Balan, C Abell, AG Coyne
– Bioorg Med Chem Lett
(2016)
26,
3735
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Research Group

Telephone number

01223 336055

Email address

agc40@cam.ac.uk