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Yusuf Hamied Department of Chemistry





Targeting Mycobacterium tuberculosis CoaBC through Chemical Inhibition of 4′-Phosphopantothenoyl- l -cysteine Synthetase (CoaB) Activity
JC Evans, D Murugesan, JM Post, V Mendes, Z Wang, N Nahiyaan, SL Lynch, S Thompson, SR Green, PC Ray, J Hess, C Spry, AG Coyne, C Abell, HIM Boshoff, PG Wyatt, KY Rhee, TL Blundell, CE Barry, V Mizrahi
– ACS infectious diseases
A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death.
DE Scott, NJ Francis-Newton, ME Marsh, AG Coyne, G Fischer, T Moschetti, AR Bayly, TD Sharpe, KT Haas, L Barber, CR Valenzano, R Srinivasan, DJ Huggins, M Lee, A Emery, B Hardwick, M Ehebauer, C Dagostin, A Esposito, L Pellegrini, T Perrior, G McKenzie, TL Blundell, M Hyvönen, J Skidmore, AR Venkitaraman, C Abell
– Cell chemical biology
Chris Abell 1957–2020
FJ Leeper, AG Coyne
– The Biochemist
Inhibiting Mycobacterium tuberculosis CoaBC by targeting an allosteric site.
V Mendes, SR Green, JC Evans, J Hess, M Blaszczyk, C Spry, O Bryant, J Cory-Wright, DS-H Chan, PHM Torres, Z Wang, N Nahiyaan, S O'Neill, S Damerow, J Post, T Bayliss, SL Lynch, AG Coyne, PC Ray, C Abell, KY Rhee, HIM Boshoff, CE Barry, V Mizrahi, PG Wyatt, TL Blundell
– Nature Communications
A fragment-based approach to assess the ligandability of ArgB, ArgC, ArgD and ArgF in the L-arginine biosynthetic pathway of Mycobacterium tuberculosis.
P Gupta, SE Thomas, SA Zaidan, MA Pasillas, J Cory-Wright, V Sebastián-Pérez, A Burgess, E Cattermole, C Meghir, C Abell, AG Coyne, WR Jacobs, TL Blundell, S Tiwari, V Mendes
– Computational and Structural Biotechnology Journal
Chemical validation of Mycobacterium tuberculosis phosphopantetheine adenylyltransferase using fragment linking and CRISPR interference
J El Bakali, M Blaszczyk, J Evans, J Boland, W McCarthy, M Dias, A Coyne, V Mizrahi, T Blundell, C Abell, C Spry
Fragment-based discovery of a new class of inhibitors targeting mycobacterial tRNA modification.
SE Thomas, AJ Whitehouse, K Brown, S Burbaud, JM Belardinelli, J Sangen, R Lahiri, MDJ Libardo, P Gupta, S Malhotra, HIM Boshoff, M Jackson, C Abell, AG Coyne, TL Blundell, RA Floto, V Mendes
– Nucleic Acids Research
Using a Fragment-Based Approach to Identify Alternative Chemical Scaffolds Targeting Dihydrofolate Reductase from Mycobacterium tuberculosis.
JA Ribeiro, A Hammer, GA Libreros-Zúñiga, SM Chavez-Pacheco, P Tyrakis, GS de Oliveira, T Kirkman, J El Bakali, SA Rocco, ML Sforça, R Parise-Filho, AG Coyne, TL Blundell, C Abell, MVB Dias
– ACS Infectious Diseases
Fragment-Based Design of Mycobacterium tuberculosis InhA Inhibitors.
M Sabbah, V Mendes, RG Vistal, DMG Dias, M Záhorszká, K Mikušová, J Korduláková, AG Coyne, TL Blundell, C Abell
– J Med Chem
Covalent inactivation of Mycobacterium thermoresistibile inosine-5 '-monophosphate dehydrogenase (IMPDH)
A Trapero, A Pacitto, DS-H Chan, C Abell, TL Blundell, DB Ascher, AG Coyne
– Bioorganic and Medicinal Chemistry Letters
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