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Yusuf Hamied Department of Chemistry

 

Dr Anthony Coyne

Principle Research Associate

 

 

Publications

Fragment‐Merging Strategies with Known Pyrimidine Scaffolds Targeting Dihydrofolate Reductase from Mycobacterium tuberculosis
T Kirkman, S Fun Tan, SM Chavez-Pacheco, A Hammer, C Abell, M Tosin, AG Coyne, MVB Dias
– ChemMedChem
(2023)
18,
e202300240
(doi: 10.1002/cmdc.202300240)
Chemical Validation of Mycobacterium tuberculosis Phosphopantetheine Adenylyltransferase Using Fragment Linking and CRISPR Interference**
J El Bakali, M Blaszczyk, JC Evans, JA Boland, WJ McCarthy, I Fathoni, MVB Dias, EO Johnson, AG Coyne, V Mizrahi, TL Blundell, C Abell, C Spry
– Angewandte Chemie
(2023)
135,
(doi: 10.1002/ange.202300221)
Structure Based Discovery of Inhibitors of CYP125 and CYP142 from Mycobacterium tuberculosis
MM Katariya, M Snee, RB Tunnicliffe, ME Kavanagh, HIM Boshoff, CN Amadi, CW Levy, AW Munro, C Abell, D Leys, AG Coyne, KJ McLean
– Chemistry
(2023)
29,
e202203868
(doi: 10.1002/chem.202203868)
Pantothenate biosynthesis in Toxoplasma gondii tachyzoites is not a drug target.
VM Howieson, J Zeng, J Kloehn, C Spry, C Marchetti, M Lunghi, E Varesio, A Soper, AG Coyne, C Abell, GG van Dooren, KJ Saliba
– Int J Parasitol Drugs Drug Resist
(2023)
22,
1
(doi: 10.1016/j.ijpddr.2023.03.003)
Chemical Validation of Mycobacterium tuberculosis Phosphopantetheine Adenylyltransferase Using Fragment Linking and CRISPR Interference**
J El Bakali, M Blaszczyk, JC Evans, JA Boland, WJ McCarthy, I Fathoni, MVB Dias, EO Johnson, AG Coyne, V Mizrahi, TL Blundell, C Abell, C Spry
– Angew Chem Int Ed Engl
(2023)
62,
e202300221
(doi: 10.1002/anie.202300221)
Microfluidic preparation of composite hydrogel microparticles for the staining of microalgal cells.
T Leontidou, Z Yu, J Hess, K Geisler, AG Smith, A Coyne, C Abell
– Colloids Surf B Biointerfaces
(2022)
221,
113026
(doi: 10.1016/j.colsurfb.2022.113026)
Development of potent inhibitors by fragment‐linking strategies
EV Bedwell, WJ McCarthy, AG Coyne, C Abell
– Chem Biol Drug Des
(2022)
100,
469
(doi: 10.1111/cbdd.14120)
Structural Characterization of Mycobacterium abscessus Phosphopantetheine Adenylyl Transferase Ligand Interactions: Implications for Fragment-Based Drug Design
SE Thomas, WJ McCarthy, J El Bakali, KP Brown, SY Kim, M Blaszczyk, V Mendes, C Abell, RA Floto, AG Coyne, TL Blundell
– Front Mol Biosci
(2022)
9,
880432
(doi: 10.3389/fmolb.2022.880432)
Potential therapeutic targets from Mycobacterium abscessus (Mab): recently reported efforts towards the discovery of novel antibacterial agents to treat Mab infections
W Addison, M Frederickson, AG Coyne, C Abell
– RSC Med Chem
(2022)
13,
392
(doi: 10.1039/d1md00359c)
Discovery of Novel Inhibitors of Uridine Diphosphate-N-Acetylenolpyruvylglucosamine Reductase (MurB) from Pseudomonas aeruginosa, an Opportunistic Infectious Agent Causing Death in Cystic Fibrosis Patients.
M Acebrón-García-de-Eulate, J Mayol-Llinàs, MTO Holland, SY Kim, KP Brown, C Marchetti, J Hess, O Di Pietro, V Mendes, C Abell, RA Floto, AG Coyne, TL Blundell
– Journal of Medicinal Chemistry
(2022)
65,
2149
(doi: 10.1021/acs.jmedchem.1c01684)
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Telephone number

01223 336055

Email address

agc40@cam.ac.uk

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