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Department of Chemistry

 

Dr Anthony Coyne

 

 

Publications

Covalent Inactivation of Mycobacterium thermoresistibile inosine-5́-monophosphate dehydrogenase (IMPDH)
A Trapero, A Pacitto, DS-H Chan, C Abell, TL Blundell, DB Ascher, AG Coyne
– Bioorganic & medicinal chemistry letters
(2020)
30,
126792
(DOI: 10.1016/j.bmcl.2019.126792)
Allosteric small-molecule serine/threonine kinase inhibitors
RC Panicker, S Chattopadhaya, AG Coyne, R Srinivasan
– Advances in experimental medicine and biology
(2019)
1163,
253
(DOI: 10.1007/978-981-13-8719-7_11)
Targeting of Fumarate Hydratase from Mycobacterium tuberculosis Using Allosteric Inhibitors with a Dimeric-Binding Mode.
AJ Whitehouse, MDJ Libardo, M Kasbekar, PD Brear, G Fischer, CJ Thomas, CE Barry, HIM Boshoff, AG Coyne, C Abell
– Journal of Medicinal Chemistry
(2019)
62,
10586
(DOI: 10.1021/acs.jmedchem.9b01203)
Structural insights into Escherichia coli phosphopantothenoylcysteine synthetase by native ion mobility–mass spectrometry
DS-H Chan, J Hess, E Shaw, C Spry, R Starley, C Dagostin, MVB Dias, R Kale, V Mendes, TL Blundell, AG Coyne, C Abell
– Biochem J
(2019)
476,
3125
(DOI: 10.1042/bcj20190318)
Development of Inhibitors against Mycobacterium abscessus tRNA (m1G37) Methyltransferase (TrmD) Using Fragment-Based Approaches.
AJ Whitehouse, SE Thomas, KP Brown, A Fanourakis, DS-H Chan, MDJ Libardo, V Mendes, HIM Boshoff, RA Floto, C Abell, TL Blundell, AG Coyne
– J Med Chem
(2019)
62,
7210
(DOI: 10.1021/acs.jmedchem.9b00809)
Structure-guided fragmentbased drug discovery at the synchrotron: Screening binding sites and correlations with hotspot mapping
SE Thomas, P Collins, RH James, V Mendes, S Charoensutthivarakul, C Radoux, C Abell, AG Coyne, RA Floto, F von Delft, TL Blundell
– Philos Trans A Math Phys Eng Sci
(2019)
377,
20180422
(DOI: 10.1098/rsta.2018.0422)
meta-Nitration of Arenes Bearing ortho/para Directing Group(s) Using C−H Borylation
X Li, X Deng, AG Coyne, R Srinivasan
– Chemistry
(2019)
25,
8018
(DOI: 10.1002/chem.201901633)
Fragment-Based Approach to Targeting Inosine-5'-monophosphate Dehydrogenase (IMPDH) from Mycobacterium tuberculosis.
A Trapero, A Pacitto, V Singh, M Sabbah, AG Coyne, V Mizrahi, TL Blundell, DB Ascher, C Abell
– Journal of Medicinal Chemistry
(2018)
61,
2806
(DOI: 10.1021/acs.jmedchem.7b01622)
Mass spectrometry for fragment screening.
DS-H Chan, AJ Whitehouse, AG Coyne, C Abell
– Essays in Biochemistry
(2017)
61,
465
(DOI: 10.1042/EBC20170071)
Effect of DMSO on Protein Structure and Interactions Assessed by Collision-Induced Dissociation and Unfolding.
DS-H Chan, ME Kavanagh, KJ McLean, AW Munro, D Matak-Vinković, AG Coyne, C Abell
– Anal Chem
(2017)
89,
9976
(DOI: 10.1021/acs.analchem.7b02329)
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Research Group

Telephone number

01223 336055

Email address

agc40@cam.ac.uk

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