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Department of Chemistry

 

Dr Anthony Coyne

 

 

Publications

A fragment-based approach to targeting inosine-5´- monophosphate dehydrogenase (IMPDH) from Mycobacterium tuberculosis
A Trapero, A Pacitto, V Singh, M Sabbah, AG Coyne, V Mizrahi, TL Blundell, DB Ascher, C Abell
– J Med Chem
(2018)
61,
2806
(DOI: 10.1021/acs.jmedchem.7b01622)
Mass spectrometry for fragment screening
DS-H Chan, AJ Whitehouse, AG Coyne, C Abell
– Essays Biochem
(2017)
61,
465
(DOI: 10.1042/ebc20170071)
Effect of DMSO on Protein Structure and Interactions Assessed by Collision-Induced Dissociation and Unfolding.
DS-H Chan, ME Kavanagh, KJ McLean, AW Munro, D Matak-Vinković, AG Coyne, C Abell
– Anal Chem
(2017)
89,
9976
(DOI: 10.1021/acs.analchem.7b02329)
Allosteric Targeting of Aurora A Kinase Using Small Molecules: A Step Forward Towards Next Generation Medicines?
RC Panicker, AG Coyne, R Srinivasan
– Current medicinal chemistry
(2017)
24,
(DOI: 10.2174/0929867324666170727120315)
Fragment Screening against the EthR–DNA Interaction by Native Mass Spectrometry
DS-H Chan, V Mendes, SE Thomas, BN McConnell, D Matak-Vinković, AG Coyne, TL Blundell, C Abell
– Angew Chem Int Ed Engl
(2017)
56,
7488
(DOI: 10.1002/anie.201702888)
Structural insights into the EthR–DNA interaction using native mass spectrometry
D Shiu-Hin Chan, W-G Seetoh, BN McConnell, D Matak-Vinković, SE Thomas, V Mendes, M Blaszczyk, AG Coyne, TL Blundell, C Abell
– Chemical communications (Cambridge, England)
(2017)
53,
3527
(DOI: 10.1039/c7cc00804j)
Fragment Profiling Approach to Inhibitors of the Orphan M. tuberculosis P450 CYP144A1
ME Kavanagh, J Chenge, A Zoufir, KJ McLean, AG Coyne, A Bender, AW Munro, C Abell
– Biochemistry
(2017)
56,
1559
(DOI: 10.1021/acs.biochem.6b00954)
Structural Characterization and Ligand/Inhibitor Identification Provide Functional Insights into the Mycobacterium tuberculosis Cytochrome P450 CYP126A1.
JT Chenge, LV Duyet, S Swami, KJ McLean, ME Kavanagh, AG Coyne, SEJ Rigby, MR Cheesman, HM Girvan, CW Levy, B Rupp, JP von Kries, C Abell, D Leys, AW Munro
– J Biol Chem
(2017)
292,
1310
(DOI: 10.1074/jbc.m116.748822)
Corrigendum: Substrate Fragmentation for the Design of M. tuberculosis CYP121 Inhibitors.
ME Kavanagh, JL Gray, SH Gilbert, AG Coyne, KJ McLean, HJ Davis, AW Munro, C Abell
– ChemMedChem
(2017)
12,
194
(DOI: 10.1002/cmdc.201600619)
Organic synthesis reactions on-water at the organic-liquid water interface.
RN Butler, AG Coyne
– Org Biomol Chem
(2016)
14,
9945
(DOI: 10.1039/c6ob01724j)
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Research Group

Telephone number

01223 336055

Email address

agc40@cam.ac.uk

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