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Yusuf Hamied Department of Chemistry

 

Dr Anthony Coyne

 

 

Publications

Inhibiting Mycobacterium tuberculosis CoaBC by targeting an allosteric site.
V Mendes, SR Green, JC Evans, J Hess, M Blaszczyk, C Spry, O Bryant, J Cory-Wright, DS-H Chan, PHM Torres, Z Wang, N Nahiyaan, S O'Neill, S Damerow, J Post, T Bayliss, SL Lynch, AG Coyne, PC Ray, C Abell, KY Rhee, HIM Boshoff, CE Barry, V Mizrahi, PG Wyatt, TL Blundell
– Nat Commun
(2021)
12,
143
(DOI: 10.1038/s41467-020-20224-x)
Using a Fragment-Based Approach to Identify Alternative Chemical Scaffolds Targeting Dihydrofolate Reductase from Mycobacterium tuberculosis
JA Ribeiro, A Hammer, GA Libreros-Zúñiga, SM Chavez-Pacheco, P Tyrakis, GS de Oliveira, T Kirkman, J El Bakali, SA Rocco, ML Sforça, R Parise-Filho, AG Coyne, TL Blundell, C Abell, MVB Dias
– ACS infectious diseases
(2020)
6,
2192
(DOI: 10.1021/acsinfecdis.0c00263)
Fragment-based discovery of a new class of inhibitors targeting mycobacterial tRNA modification.
SE Thomas, AJ Whitehouse, K Brown, S Burbaud, JM Belardinelli, J Sangen, R Lahiri, MDJ Libardo, P Gupta, S Malhotra, HIM Boshoff, M Jackson, C Abell, AG Coyne, TL Blundell, RA Floto, V Mendes
– Nucleic Acids Research
(2020)
48,
8099
(DOI: 10.1093/nar/gkaa539)
Fragment-Based Design of Mycobacterium tuberculosis InhA Inhibitors.
M Sabbah, V Mendes, RG Vistal, DMG Dias, M Záhorszká, K Mikušová, J Korduláková, AG Coyne, TL Blundell, C Abell
– Journal of medicinal chemistry
(2020)
63,
4749
(DOI: 10.1021/acs.jmedchem.0c00007)
Covalent inactivation of Mycobacterium thermoresistibile inosine-5′-monophosphate dehydrogenase (IMPDH)
A Trapero, A Pacitto, DS-H Chan, C Abell, TL Blundell, DB Ascher, AG Coyne
– Bioorganic & Medicinal Chemistry Letters
(2020)
30,
126792
(DOI: 10.1016/j.bmcl.2019.126792)
Allosteric small-molecule serine/threonine kinase inhibitors
RC Panicker, S Chattopadhaya, AG Coyne, R Srinivasan
– Adv Exp Med Biol
(2019)
1163,
253
(DOI: 10.1007/978-981-13-8719-7_11)
Targeting of Fumarate Hydratase from Mycobacterium tuberculosis Using Allosteric Inhibitors with a Dimeric-Binding Mode.
AJ Whitehouse, MDJ Libardo, M Kasbekar, PD Brear, G Fischer, CJ Thomas, CE Barry, HIM Boshoff, AG Coyne, C Abell
– J Med Chem
(2019)
62,
10586
(DOI: 10.1021/acs.jmedchem.9b01203)
Structural insights into Escherichia coli phosphopantothenoylcysteine synthetase by native ion mobility–mass spectrometry
DS-H Chan, J Hess, E Shaw, C Spry, R Starley, C Dagostin, MVB Dias, R Kale, V Mendes, TL Blundell, AG Coyne, C Abell
– Biochemical Journal
(2019)
476,
3125
(DOI: 10.1042/BCJ20190318)
Development of Inhibitors against Mycobacterium abscessus tRNA (m1G37) Methyltransferase (TrmD) Using Fragment-Based Approaches
AJ Whitehouse, SE Thomas, KP Brown, A Fanourakis, DS-H Chan, MDJ Libardo, V Mendes, HIM Boshoff, RA Floto, C Abell, TL Blundell, AG Coyne
– J Med Chem
(2019)
62,
7210
(DOI: 10.1021/acs.jmedchem.9b00809)
Structure-guided fragment-based drug discovery at the synchrotron: screening binding sites and correlations with hotspot mapping.
SE Thomas, P Collins, RH James, V Mendes, S Charoensutthivarakul, C Radoux, C Abell, AG Coyne, RA Floto, F von Delft, TL Blundell
– Philosophical Transactions of the Royal Society A Mathematical Physical and Engineering Sciences
(2019)
377,
20180422
(DOI: 10.1098/rsta.2018.0422)
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Telephone number

01223 336055

Email address

agc40@cam.ac.uk

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