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Department of Chemistry

Fixed-term: The funds for this post are available for 3 years in the first instance.

Applications are invited for a Post-doctoral Research Associate who will be based in the Department of Chemistry, University of Cambridge to carry out single aggregate imaging and characterisation of samples of cerebrospinal fluid and serum from individuals with Parkinson's disease.

Building on strong preliminary data, the aim of the project is to identify and characterise the damaging aggregates that form in serum and cerebrospinal fluid of individuals, as they develop Parkinson's disease, in a collaborative project with Dr Caroline Williams-Grey in the Department of Clinical Neuroscience. A suite of ultra-sensitive biophysical methods developed in the Klenerman group (see Angew.Chem.Int. (2017) 56, 7750, ChemBioChem (2018) 19, 2033, Nature Comm. (2019), 10,1541 and Acta Neuropathologica Communications (2019) 7,120) will be used that can detect and characterise unlabelled protein aggregates in human biofluids. In particular the project will explore the exciting possibility of detecting aggregates in serum for early disease diagnosis.

Applicants should have (or be about to obtain) a PhD in fluorescence microscopy, biophysics or single molecule fluorescence, experience of using home built imaging equipment and interest in performing multi-disciplinary research in a team. This is an ideal opportunity for a physically trained scientist to apply cutting-edge imaging methods to tackle a major biomedical problem.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Please ensure that you upload your Curriculum Vitae (CV), a covering letter and publications list in the upload section of the online application. If you upload any additional documents that have not been requested, we will not be able to consider these as part of your application.

Further details about the post can be obtained from Prof. Dave Klenerman (

Please quote reference MA20520 on your application and in any correspondence about this vacancy.

The Department holds an Athena SWAN silver award for women in Science, Technology, Engineering, Mathematics, and Medicine.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Apply online

Closing date

Oct 25th 2019

Reference number




Further Information

Further information

Athena SWAN