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The Clarke Group

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  • Currently displaying 21 - 40 of 163 publications
Editorial overview: Folding and binding: Protein folding and binding, complexity comes of age
J Clarke, RV Pappu
– Curr Opin Struct Biol
(2017)
42,
v
Disorder drives cooperative folding in a multidomain protein.
DT Gruszka, CATF Mendonça, E Paci, F Whelan, J Hawkhead, JR Potts, J Clarke
– Proceedings of the National Academy of Sciences
(2016)
113,
11841
Cotranslational folding studies of spectrin and Ig-like domains show folding occurs close to the ribosome
A Steward, OB Nilsson, AA Nickson, JJ Hollins, S Wickles, A Marsden, C Mendonca, R Beckmann, G von Heijne, J Clarke
– PROTEIN SCIENCE
(2016)
25,
107
Protein folding - on and off the ribosome: Using Physics and Chemistry to understand Biology
J Clarke
– PROTEIN SCIENCE
(2016)
25,
175
GADIS: Algorithm for designing sequences to achieve target secondary structure profiles of intrinsically disordered proteins.
TS Harmon, MD Crabtree, SL Shammas, AE Posey, J Clarke, RV Pappu
– Protein engineering, design & selection : PEDS
(2016)
29,
339
The Role of Disorder in Protein Folding
J Clarke
– Biophysical Journal
(2016)
110,
196a
Plasticity of Nucleoporin Nuclear Transport Receptor Interactions - Molecular Description of a Highly Dynamic, Ultrafast Interaction Mechanism
IV Aramburu, D Mercadante, S Milles, M Ringkjobing, N Banterle, C Koehler, S Tyagi, J Clarke, SL Shammas, M Blackledge, F Graeter, EA Lemke
– BIOPHYSICAL JOURNAL
(2016)
110,
357A
Insights into Coupled Folding and Binding Mechanisms from Kinetic Studies.
SL Shammas, MD Crabtree, L Dahal, BIM Wicky, J Clarke
– The Journal of biological chemistry
(2016)
291,
6689
De Novo Evolutionary Emergence of a Symmetrical Protein Is Shaped by Folding Constraints.
RG Smock, I Yadid, O Dym, J Clarke, DS Tawfik
– Cell
(2016)
164,
476
Plasticity of an ultrafast interaction between nucleoporins and nuclear transport receptors.
S Milles, D Mercadante, IV Aramburu, MR Jensen, N Banterle, C Koehler, S Tyagi, J Clarke, SL Shammas, M Blackledge, F Gräter, EA Lemke
– Cell
(2015)
163,
734
The response of greek key proteins to changes in connectivity depends on the nature of their secondary structure
KR Kemplen, D De Sancho, J Clarke
– J Mol Biol
(2015)
427,
2159
Transient misfolding dominates multidomain protein folding.
A Borgia, KR Kemplen, MB Borgia, A Soranno, S Shammas, B Wunderlich, D Nettels, RB Best, J Clarke, B Schuler
– Nat Commun
(2015)
6,
8861
Cooperative folding of intrinsically disordered domains drives assembly of a strong elongated protein.
DT Gruszka, F Whelan, OE Farrance, HKH Fung, E Paci, CM Jeffries, DI Svergun, C Baldock, CG Baumann, DJ Brockwell, JR Potts, J Clarke
– Nature communications
(2015)
6,
7271
Evolution of oligomeric state through allosteric pathways that mimic ligand binding.
T Perica, Y Kondo, SP Tiwari, SH McLaughlin, KR Kemplen, X Zhang, A Steward, N Reuter, J Clarke, SA Teichmann
– Science (New York, N.Y.)
(2014)
346,
1254346
Interplay between partner and ligand facilitates the folding and binding of an intrinsically disordered protein.
JM Rogers, V Oleinikovas, SL Shammas, CT Wong, D De Sancho, CM Baker, J Clarke
– Proceedings of the National Academy of Sciences of the United States of America
(2014)
111,
15420
Allostery within a transcription coactivator is predominantly mediated through dissociation rate constants.
SL Shammas, AJ Travis, J Clarke
– Proc Natl Acad Sci U S A
(2014)
111,
12055
Coupled folding and binding of the disordered protein PUMA does not require particular residual structure.
JM Rogers, CT Wong, J Clarke
– Journal of the American Chemical Society
(2014)
136,
5197
Mechanism of assembly of the non-covalent spectrin tetramerization domain from intrinsically disordered partners
SA Hill, LG Kwa, SL Shammas, JC Lee, J Clarke
– Journal of Molecular Biology
(2014)
426,
21
The Folding of a Family of Three-Helix Bundle Proteins: Spectrin R15 Has a Robust Folding Nucleus, Unlike Its Homologous Neighbours
LG Kwa, BG Wensley, CG Alexander, SJ Browning, BR Lichman, J Clarke
– J Mol Biol
(2014)
426,
1600
Remarkably fast coupled folding and binding of the intrinsically disordered transactivation domain of cMyb to CBP KIX
SL Shammas, AJ Travis, J Clarke
– The journal of physical chemistry. B
(2013)
117,
13346