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  • Currently displaying 1 - 20 of 381 publications
Fragment-Merging Strategies with Known Pyrimidine Scaffolds Targeting Dihydrofolate Reductase from Mycobacterium tuberculosis.
T Kirkman, S Fun Tan, SM Chavez-Pacheco, A Hammer, C Abell, M Tosin, AG Coyne, MVB Dias
– ChemMedChem
(2023)
18,
e202300240
(doi: 10.1002/cmdc.202300240)
Chemical Validation of Mycobacterium tuberculosis Phosphopantetheine Adenylyltransferase Using Fragment Linking and CRISPR Interference**
J El Bakali, M Blaszczyk, JC Evans, JA Boland, WJ McCarthy, I Fathoni, MVB Dias, EO Johnson, AG Coyne, V Mizrahi, TL Blundell, C Abell, C Spry
– Angewandte Chemie
(2023)
135,
(doi: 10.1002/ange.202300221)
Structure Based Discovery of Inhibitors of CYP125 and CYP142 from Mycobacterium tuberculosis
MM Katariya, M Snee, RB Tunnicliffe, ME Kavanagh, HIM Boshoff, CN Amadi, CW Levy, AW Munro, C Abell, D Leys, AG Coyne, KJ McLean
– Chemistry (Weinheim an der Bergstrasse, Germany)
(2023)
29,
e202203868
(doi: 10.1002/chem.202203868)
Selective inhibitors of the Aurora A-TPX2 protein-protein interaction exhibitin vivoefficacy as targeted anti-mitotic agents
S Stockwell, D Scott, G Fischer, E Guarino, T Rooney, T-S Feng, T Moschetti, R Srinivasan, E Alza, A Asteian, C Dagostin, A Alcaide, M Rocaboy, B Blaszczyk, A Higueruelo, X Wang, M Rossmann, T Perrior, T Blundell, D Spring, G McKenzie, C Abell, J Skidmore, M Hyvönen, A Venkitaraman
(2023)
(doi: 10.1101/2023.03.22.533679)
Pantothenate biosynthesis in Toxoplasma gondii tachyzoites is not a drug target.
VM Howieson, J Zeng, J Kloehn, C Spry, C Marchetti, M Lunghi, E Varesio, A Soper, AG Coyne, C Abell, GG van Dooren, KJ Saliba
– International Journal for Parasitology: Drugs and Drug Resistance
(2023)
22,
1
(doi: 10.1016/j.ijpddr.2023.03.003)
Chemical Validation of Mycobacterium tuberculosis Phosphopantetheine Adenylyltransferase Using Fragment Linking and CRISPR Interference**
J El Bakali, M Blaszczyk, JC Evans, JA Boland, WJ McCarthy, I Fathoni, MVB Dias, EO Johnson, AG Coyne, V Mizrahi, TL Blundell, C Abell, C Spry
– Angewandte Chemie International Edition
(2023)
62,
e202300221
(doi: 10.1002/anie.202300221)
Microfluidic preparation of composite hydrogel microparticles for the staining of microalgal cells
T Leontidou, Z Yu, J Hess, K Geisler, AG Smith, A Coyne, C Abell
– Colloids and Surfaces B Biointerfaces
(2022)
221,
113026
(doi: 10.1016/j.colsurfb.2022.113026)
Development of potent inhibitors by fragment‐linking strategies
EV Bedwell, WJ McCarthy, AG Coyne, C Abell
– Chemical Biology and Drug Design
(2022)
100,
469
(doi: 10.1111/cbdd.14120)
Structural Characterization of Mycobacterium abscessus Phosphopantetheine Adenylyl Transferase Ligand Interactions: Implications for Fragment-Based Drug Design
SE Thomas, WJ McCarthy, J El Bakali, KP Brown, SY Kim, M Blaszczyk, V Mendes, C Abell, RA Floto, AG Coyne, TL Blundell
– Front Mol Biosci
(2022)
9,
880432
(doi: 10.3389/fmolb.2022.880432)
Author Correction: Droplet microfluidics for the highly controlled synthesis of branched gold nanoparticles.
S Abalde-Cela, P Taladriz-Blanco, MG de Oliveira, C Abell
– Scientific Reports
(2022)
12,
6559
(doi: 10.1038/s41598-022-10761-4)
Potential therapeutic targets from Mycobacterium abscessus ( Mab ): recently reported efforts towards the discovery of novel antibacterial agents to treat Mab infections
W Addison, M Frederickson, AG Coyne, C Abell
– RSC Med Chem
(2022)
13,
392
(doi: 10.1039/d1md00359c)
Improving the efficiency and effectiveness of an industrial SARS-CoV-2 diagnostic facility
JA Douthwaite, CA Brown, JR Ferdinand, R Sharma, J Elliott, MA Taylor, NT Malintan, H Duvoisin, T Hill, O Delpuech, AL Orton, H Pitt, F Kuenzi, S Fish, DJ Nicholls, A Cuthbert, I Richards, G Ratcliffe, A Upadhyay, A Marklew, C Hewitt, D Ross-Thriepland, C Brankin, M Chodorge, G Browne, PK Mander, RM DeWildt, S Weaver, PA Smee, J van Kempen, JG Bartlett, PM Allen, EL Koppe, CA Ashby, JD Phipps, N Mehta, DJ Brierley, DG Tew, MV Leveridge, SM Baddeley, IG Goodfellow, C Green, C Abell, A Neely, I Waddell, S Rees, PH Maxwell, MN Pangalos, R Howes, R Clark
– Sci Rep
(2022)
12,
3114
(doi: 10.1038/s41598-022-06873-6)
Genomic epidemiology of SARS-CoV-2 in a UK university identifies dynamics of transmission.
D Aggarwal, B Warne, AS Jahun, WL Hamilton, T Fieldman, L du Plessis, V Hill, B Blane, E Watkins, E Wright, G Hall, C Ludden, R Myers, M Hosmillo, Y Chaudhry, ML Pinckert, I Georgana, R Izuagbe, D Leek, O Nsonwu, GJ Hughes, S Packer, AJ Page, M Metaxaki, S Fuller, G Weale, J Holgate, CA Brown, Cambridge Covid-19 testing Centre, University of Cambridge Asymptomatic COVID-19 Screening Programme Consortium, COVID-19 Genomics UK (COG-UK) Consortium, R Howes, D McFarlane, G Dougan, OG Pybus, DD Angelis, PH Maxwell, SJ Peacock, MP Weekes, C Illingworth, EM Harrison, NJ Matheson, IG Goodfellow
– Nature Communications
(2022)
13,
751
(doi: 10.1038/s41467-021-27942-w)
Discovery of Novel Inhibitors of Uridine Diphosphate- N-Acetylenolpyruvylglucosamine Reductase (MurB) from Pseudomonas aeruginosa, an Opportunistic Infectious Agent Causing Death in Cystic Fibrosis Patients
M Acebrón-García-de-Eulate, J Mayol-Llinàs, MTO Holland, SY Kim, KP Brown, C Marchetti, J Hess, O Di Pietro, V Mendes, C Abell, RA Floto, AG Coyne, TL Blundell
– Journal of Medicinal Chemistry
(2022)
65,
2149
(doi: 10.1021/acs.jmedchem.1c01684)
Development of Inhibitors of SAICAR Synthetase (PurC) from Mycobacterium abscessus Using a Fragment-Based Approach.
S Charoensutthivarakul, SE Thomas, A Curran, KP Brown, JM Belardinelli, AJ Whitehouse, M Acebrón-García-de-Eulate, J Sangan, SG Gramani, M Jackson, V Mendes, RA Floto, TL Blundell, AG Coyne, C Abell
– ACS Infectious Diseases
(2022)
8,
296
(doi: 10.1021/acsinfecdis.1c00432)
A new strategy for hit generation: Novel in cellulo active inhibitors of CYP121A1 from Mycobacterium tuberculosis via a combined X-ray crystallographic and phenotypic screening approach (XP screen)
M Frederickson, IR Selvam, D Evangelopoulos, KJ McLean, MM Katariya, RB Tunnicliffe, B Campbell, ME Kavanagh, S Charoensutthivarakul, RT Blankley, CW Levy, LPS de Carvalho, D Leys, AW Munro, AG Coyne, C Abell
– European journal of medicinal chemistry
(2022)
230,
114105
(doi: 10.1016/j.ejmech.2022.114105)
Microdroplets confined assembly of opal composites in dynamic borate ester-based networks
J Zhang, Y Qin, OJ Pambos, J Zhang, S Chen, Z Yu, C Abell
– Chemical Engineering Journal
(2021)
426,
127581
(doi: 10.1016/j.cej.2020.127581)
A fragment-based approach to assess the ligandability of ArgB, ArgC, ArgD and ArgF in the L-arginine biosynthetic pathway of Mycobacterium tuberculosis.
P Gupta, SE Thomas, SA Zaidan, MA Pasillas, J Cory-Wright, V Sebastián-Pérez, A Burgess, E Cattermole, C Meghir, C Abell, AG Coyne, WR Jacobs, TL Blundell, S Tiwari, V Mendes
– Comput Struct Biotechnol J
(2021)
19,
3491
(doi: 10.1016/j.csbj.2021.06.006)
Droplet-based microfluidic screening and sorting of microalgal populations for strain engineering applications
Z Yu, K Geisler, T Leontidou, REB Young, SE Vonlanthen, S Purton, C Abell, AG Smith
– Algal Res
(2021)
56,
102293
(doi: 10.1016/j.algal.2021.102293)
Targeting Mycobacterium tuberculosis CoaBC through Chemical Inhibition of 4'-Phosphopantothenoyl-l-cysteine Synthetase (CoaB) Activity.
JC Evans, D Murugesan, JM Post, V Mendes, Z Wang, N Nahiyaan, SL Lynch, S Thompson, SR Green, PC Ray, J Hess, C Spry, AG Coyne, C Abell, HIM Boshoff, PG Wyatt, KY Rhee, TL Blundell, CE Barry, V Mizrahi
– ACS Infect Dis
(2021)
7,
1666
(doi: 10.1021/acsinfecdis.0c00904)

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