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  • Currently displaying 1 - 20 of 361 publications
A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death
DE Scott, NJ Francis-Newton, ME Marsh, AG Coyne, G Fischer, T Moschetti, AR Bayly, TD Sharpe, KT Haas, L Barber, CR Valenzano, R Srinivasan, DJ Huggins, M Lee, A Emery, B Hardwick, M Ehebauer, C Dagostin, A Esposito, L Pellegrini, T Perrior, G McKenzie, TL Blundell, M Hyvönen, J Skidmore, AR Venkitaraman, C Abell
– Cell Chem Biol
(2021)
28,
835
Inhibiting Mycobacterium tuberculosis CoaBC by targeting an allosteric site.
V Mendes, SR Green, JC Evans, J Hess, M Blaszczyk, C Spry, O Bryant, J Cory-Wright, DS-H Chan, PHM Torres, Z Wang, N Nahiyaan, S O'Neill, S Damerow, J Post, T Bayliss, SL Lynch, AG Coyne, PC Ray, C Abell, KY Rhee, HIM Boshoff, CE Barry, V Mizrahi, PG Wyatt, TL Blundell
– Nature Communications
(2021)
12,
143
Chemical validation of Mycobacterium tuberculosis phosphopantetheine adenylyltransferase using fragment linking and CRISPR interference
J El Bakali, M Blaszczyk, J Evans, J Boland, W McCarthy, M Dias, A Coyne, V Mizrahi, T Blundell, C Abell, C Spry
(2020)
Fragment-based discovery of a new class of inhibitors targeting mycobacterial tRNA modification
SE Thomas, AJ Whitehouse, K Brown, S Burbaud, JM Belardinelli, J Sangen, R Lahiri, MDJ Libardo, P Gupta, S Malhotra, HIM Boshoff, M Jackson, C Abell, AG Coyne, TL Blundell, RA Floto, V Mendes
– Nucleic Acids Res
(2020)
48,
8099
Using a Fragment-Based Approach to Identify Alternative Chemical Scaffolds Targeting Dihydrofolate Reductase from Mycobacterium tuberculosis.
JA Ribeiro, A Hammer, GA Libreros-Zúñiga, SM Chavez-Pacheco, P Tyrakis, GS de Oliveira, T Kirkman, J El Bakali, SA Rocco, ML Sforça, R Parise-Filho, AG Coyne, TL Blundell, C Abell, MVB Dias
– ACS Infect Dis
(2020)
6,
2192
Spatially Controlled Supramolecular Polymerization of Peptide Nanotubes by Microfluidics
A Méndez‐Ardoy, A Bayón‐Fernández, Z Yu, C Abell, JR Granja, J Montenegro
– Angewandte Chemie
(2020)
132,
6969
Viscoelastic Hydrogel Microfibers Exploiting Cucurbit[8]uril Host-Guest Chemistry and Microfluidics
Z-J Meng, J Liu, Z Yu, H Zhou, X Deng, C Abell, OA Scherman
– ACS Appl Mater Interfaces
(2020)
12,
17929
Fragment-Based Design of Mycobacterium tuberculosis InhA Inhibitors
M Sabbah, V Mendes, RG Vistal, DMG Dias, M Záhorszká, K Mikušová, J Korduláková, AG Coyne, TL Blundell, C Abell
– Journal of Medicinal Chemistry
(2020)
63,
4749
Spatially Controlled Supramolecular Polymerization of Peptide Nanotubes by Microfluidics.
A Méndez-Ardoy, A Bayón-Fernández, Z Yu, C Abell, JR Granja, J Montenegro
– Angew Chem Int Ed Engl
(2020)
59,
6902
Covalent inactivation of Mycobacterium thermoresistibile inosine-5 '-monophosphate dehydrogenase (IMPDH)
A Trapero, A Pacitto, DS-H Chan, C Abell, TL Blundell, DB Ascher, AG Coyne
– Bioorg Med Chem Lett
(2020)
30,
126792
Fragment-Based Design of Mycobacterium Tuberculosis InhA Inhibitors
M Sabbah, V Mendes, RG Vistal, DMG Dias, M Záhorszká, K Mikušová, J Korduláková, A Coyne, TL Blundell, C Abell
(2020)
Fragment-Based Design of Mycobacterium Tuberculosis InhA Inhibitors
M Sabbah, V Mendes, R Vistal, D Dias, M Záhorszká, K Mikušová, J Korduláková, A Coyne, T Blundell, C Abell
(2020)
Construction of core-shell microcapsules via focused surface acoustic wave microfluidics.
S Jin, X Wei, J Ren, Z Jiang, C Abell, Z Yu
– Lab on a Chip
(2020)
20,
3104
Fragment-Based Design of Mycobacterium Tuberculosis InhA Inhibitors
M Sabbah, V Mendes, R Vistal, D Dias, J Korduláková, K Mikušová, A Coyne, T Blundell, C Abell
(2019)
Targeting of Fumarate Hydratase from Mycobacterium tuberculosis Using Allosteric Inhibitors with a Dimeric-Binding Mode.
AJ Whitehouse, MDJ Libardo, M Kasbekar, PD Brear, G Fischer, CJ Thomas, CE Barry, HIM Boshoff, AG Coyne, C Abell
– Journal of medicinal chemistry
(2019)
62,
10586
Structural insights into Escherichia coli phosphopantothenoylcysteine synthetase by native ion mobility–mass spectrometry
DS-H Chan, J Hess, E Shaw, C Spry, R Starley, C Dagostin, MVB Dias, R Kale, V Mendes, TL Blundell, AG Coyne, C Abell
– Biochem J
(2019)
476,
3125
Motile Artificial Chromatophores: Light‐Triggered Nanoparticles for Microdroplet Locomotion and Color Change
AR Salmon, S Cormier, W Wang, C Abell, JJ Baumberg
– Advanced Optical Materials
(2019)
7,
1900951
Focused surface acoustic waves induced microdroplets generation and its application for microgels
S Jin, X Wei, Z Liu, J Ren, Z Jiang, C Abell, Z Yu
– Sensors and Actuators, B: Chemical
(2019)
291,
1
Development of Inhibitors against Mycobacterium abscessus tRNA (m1G37) Methyltransferase (TrmD) Using Fragment-Based Approaches.
AJ Whitehouse, SE Thomas, KP Brown, A Fanourakis, DS-H Chan, MDJ Libardo, V Mendes, HIM Boshoff, RA Floto, C Abell, TL Blundell, AG Coyne
– Journal of Medicinal Chemistry
(2019)
62,
7210
Bioinspired hydrogel microfibres colour-encoded with colloidal crystals
ZJ Meng, J Zhang, X Deng, J Liu, Z Yu, C Abell
– Materials Horizons
(2019)
6,
1938