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The Abell Group

Fragment based drug discovery against cytochrome P450s from Mycobacterium tuberculosis

We are using fragment-based approaches to understand of the role of cytochrome P450 enzymes (CYPs) from Mycobacterium tuberculosis. CYPs are mon-oxygenases responsible for a range of oxidative modifications. M. tuberculosis has a relatively high number of CYPs, some of which are essential, and some of which are of unknown function.

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Targeting the Coenzyme A pathway

We have a long term interest in the enzymology of Coenzyme A, both the pathway up to pantothenate (vitamin B5) (present in plants, microorganisms and fungi) and the pathway from pantothenate to Coenzyme A (present in all cells). We have a specific interest in targeting the coenzyme A pathway enzymes (CoaBC, CoaD, CoaE) from Mycobacterium tuberculosis.

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Antibiotics for bacteria infections in cystic fibrosis

We are interested in using fragment based approaches to develop novel antibiotics for two multi-drug resistant bacterial infections affecting people with Cystic Fibrosis. We are interested in targeting enzymes from Mycobacterium abscessus and Pseudomonas aeruginosa.

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Microdroplets reactors

We develop microfluidic microdroplet reactors for applications in biology and material sciences. Experiments are carried out in small water droplets, separated from each other by a continuous oil phase, within a microfluidic channel. We develop devices to generate and manipulate the droplets, and develop new analytical approaches to follow what is happening, on a very small scale, inside the droplets.

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Professor Chris Abell FRS FMedSci

Pro-Vice-Chancellor for Research

Professor of Biological Chemistry

Todd-Hamied Fellow of Christ's College

Co-founder of Astex Pharmaceuticals

Co-founder of Sphere Fluidics

Co-founder of Aqdot

Spin-out companies

 

Astex PharmaceuticalsSphere Fluidics LtdAqdot