Discovery of potent inhibitors of α-synuclein aggregation using structure-based iterative learning
– Nature Chemical Biology
(2024)
1
(DOI: 10.1038/s41589-024-01580-x)
Pharmacological inhibition of α-synuclein aggregation within liquid condensates
– Nature Communications
(2024)
(DOI: 10.1038/s41467-024-47585-x)
RASP: Optimal Single Puncta Detection in Complex Cellular Backgrounds.
– The Journal of Physical Chemistry B
(2024)
128,
3585
(DOI: 10.1021/acs.jpcb.4c00174)
Understanding Biology in the Age of Artificial Intelligence
(2024)
A Relationship Between Structures and Neurotoxic Effects of Aβ Oligomers Stabilized by Different Metal Ions
– ACS Chem Neurosci
(2024)
15,
1125
(DOI: 10.1021/acschemneuro.3c00718)
An upstream G-quadruplex DNA structure can stimulate gene transcription
– ACS Chemical Biology
(2024)
19,
736
(DOI: 10.1021/acschembio.3c00775)
Misfolded protein oligomers: mechanisms of formation, cytotoxic effects, and pharmacological approaches against protein misfolding diseases
– Molecular Neurodegeneration
(2024)
19,
20
(DOI: 10.1186/s13024-023-00651-2)
Large-scale visualisation of α-synuclein oligomers in Parkinson’s disease brain tissue
(2024)
(DOI: 10.1101/2024.02.17.580698)
Cathepsin B Processing Is Required for the <i>In Vivo</i> Efficacy of Albumin–Drug Conjugates
– Bioconjugate chemistry
(2024)
35,
132
Modulation of α-synuclein in vitro aggregation kinetics by its alternative splice isoforms
– Proceedings of the National Academy of Sciences
(2024)
121,
e2313465121
(DOI: 10.1073/pnas.2313465121)
Maturation-dependent changes in the size, structure and seeding capacity of Aβ42 amyloid fibrils
– Communications Biology
(2024)
7,
153
(DOI: 10.1038/s42003-024-05858-7)
G-quadruplex DNA structure is a positive regulator of MYC transcription
– Proc Natl Acad Sci U S A
(2024)
121,
e2320240121
(DOI: 10.1073/pnas.2320240121)
Imaging Aβ aggregation by liquid-phase transmission electron microscopy
(2024)
(DOI: 10.1101/2024.01.29.577710)
Transient interactions between the fuzzy coat and the cross-β core of brain-derived Aβ42 filaments
(2024)
(DOI: 10.21203/rs.3.rs-3847495/v1)
Establishing a synthetic orthogonal replication system enables accelerated evolution in E. coli
– Science (New York, N.Y.)
(2024)
383,
421
(DOI: 10.1126/science.adk1281)
Improving Antibody Humanness Prediction using Patent Data
(2024)
Using Generative Modeling to Endow with Potency Initially Inert Compounds with Good Bioavailability and Low Toxicity.
– Journal of chemical information and modeling
(2024)
64,
590
(DOI: 10.1021/acs.jcim.3c01777)
Assessing antibody and nanobody nativeness for hit selection and humanization with AbNatiV
– Nature Machine Intelligence
(2024)
6,
74
(DOI: 10.1038/s42256-023-00778-3)