Publications by Professor David Spring

Surface swarming motility by Pectobacterium atrosepticum is a latent phenotype that requires O antigen and is regulated by quorum sensing.

SD Bowden, N Hale, JC Chung, JT Hodgkinson, DR Spring, M Welch - Microbiology (2013)
(DOI: 10.1099/mic.0.070748-0)

Combating Multidrug-Resistant Bacteria: Current Strategies for the Discovery of Novel Antibacterials.

KMG O'Connell, JT Hodgkinson, HF Sore, M Welch, GPC Salmond, DR Spring - Angew Chem Int Ed Engl (2013), n/a
(DOI: 10.1002/anie.201209979)

A strategy for the diversity-oriented synthesis of macrocyclic scaffolds using multidimensional coupling

HSG Beckmann, F Nie, CE Hagerman, H Johansson, YS Tan, D Wilcke, DR Spring - Nature Chemistry (2013)
(DOI: 10.1038/nchem.1729)

Virulence in Pectobacterium atrosepticum is regulated by a coincidence circuit involving quorum sensing and the stress alarmone, (p)ppGpp.

SD Bowden, A Eyres, JC Chung, RE Monson, A Thompson, GP Salmond, DR Spring, M Welch - Mol Microbiol (2013), n/a
(DOI: 10.1111/mmi.12369)

Ligand binding kinetics of the quorum sensing regulator PqsR

M Welch, JT Hodgkinson, J Gross, DR Spring, T Sams - Biochemistry (2013) 52, 4433
(DOI: 10.1021/bi400315s)

Mild and efficient synthesis of benzo-fused seven- and eight-membered ring lactams: A convenient approach to biologically interesting chemotypes

JL Kenwright, WRJD Galloway, L Wortmann, DR Spring - Synthetic Communications (2013) 43, 1508
(DOI: 10.1080/00397911.2011.643439)

A lysosome-targetable fluorescent probe for imaging hydrogen sulfide in living cells

T Liu, Z Xu, DR Spring, J Cui - Organic Letters (2013) 15, 2310
(DOI: 10.1021/ol400973v)

Dynamic Combinatorial Chemistry with Novel Dithiol Building Blocks: Towards New Structurally Diverse and Adaptive Screening Collections

TM Postma, WRJD Galloway, FBL Cougnon, GD Pantoş, JE Stokes, DR Spring - Synlett (2013) 24, 765
(DOI: 10.1055/s-0032-1318407)

Inhibition of the production of the Pseudomonas aeruginosa virulence factor pyocyanin in wild-type cells by quorum sensing autoinducer-mimics

B Morkunas, WRJD Galloway, M Wright, BM Ibbeson, JT Hodgkinson, KMG O'Connell, N Bartolucci, MD Valle, M Welch, DR Spring - Organic and Biomolecular Chemistry (2012) 10, 8452
(DOI: 10.1039/c2ob26501j)

A two-directional strategy for the diversity-oriented synthesis of macrocyclic scaffolds.

KMG O'Connell, HSG Beckmann, L Laraia, HT Horsley, A Bender, AR Venkitaraman, DR Spring - Organic and Biomolecular Chemistry (2012) 10, 7545
(DOI: 10.1039/c2ob26272j)