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Professor Markus Kalberer

Portrait of mk594

Chemistry of atmospheric aerosols and their effects on human health

Atmospheric aerosol particles (with a size range of a few nanometers to tens of micrometers) are key components in the climate system and are associated with respiratory and cardio-vascular diseases. In both areas the chemical composition and reactivity of aerosol particles are important.

Our research activities include:

Analysis of the composition of organic aerosols

About 30-50% of atmospheric aerosol particles are composed of organic material. The chemical composition, formation pathways, and reactions of this organic material are poorly characterised.

To gain more detailed insights into the chemical composition of organic aerosols, we are using a number of state-of-the-art analytical-chemical techniques, including ultra- high resolution mass spectrometry, NMR and chromatographic methods. Changes in the organic composition of the aerosols due to atmospheric oxidation reactions are investigated, and the corresponding changes in the climate forcing and toxicity of the aerosol are explored. We are generating and reacting aerosol particles in laboratory experiments or analyse particles collected from the ambient atmosphere.

The emphasis of these analyses is currently on elucidating the role of the recently discovered high molecular weight organic oligomers and humic-like substances that are often found in atmospheric aerosol.

(a) Mass spectrum (MS) of organic aerosol particles, generated and oxidized in a laboratory set-up. Hundreds of small oligomers are generated with masses up to 1000 m/z (Kalberer et al., Science, 2004).

(b) If measured with a high resolution mass spectrometer, the elemental composition of all compounds in a MS can be determined. The oxygen to carbon atom ratios are shown here for all higher molecular weight compounds in the MS of another laboratory aerosols sample (dots represent peaks in the original MS), which allows the deduction of possible formation mechanisms and structures of oligomers and monomers (Reinhardt et al., Anal.Chem., 2007).

Development of analytical-chemical instrumentation

To advance our knowledge of the chemical composition of aerosols novel analytical methods and instrumentation are required. Recently we have introduced a number of new analytical techniques to the field of atmospheric sciences, most notable in the field of mass spectrometry. We are currently developing analytical methods and instruments to identify and quantify the components of aerosol that are relevant to human health effects.

Interactions of aerosol particles with the lung

Epidemiological studies have shown correlations between aerosol particle exposure and a range of adverse health effects. However, the interaction of particles with the lung, the main pathway of undesired particle uptake, are not well known and a mechanistic understanding of particle effects in lung cells is lacking. We recently built a particle deposition chamber, which allows for an accurate deposition of nanometer sized aerosol particles on lung cell cultures mimicking accurately the in vivo physiological conditions. In collaboration with cell biologists and toxicologists we are investigating the effects of particle composition and particle source on the biochemical and physiological responses of lung cells.


Comprehensive modeling study of ozonolysis of oleic acid aerosol based on real-time, online measurements of aerosol composition
PJ Gallimore, PT Griffiths, FD Pope, JP Reid, M Kalberer
– Journal of Geophysical Research: Atmospheres
Online Quantification of Criegee Intermediates of alpha-Pinene Ozonolysis by Stabilization with Spin Traps and Proton-Transfer Reaction Mass Spectrometry Detection
C Giorio, SJ Campbell, M Bruschi, F Tampieri, A Barbon, A Toffoletti, A Tapparo, C Paijens, AJ Wedlake, P Grice, DJ Howe, M Kalberer
– Journal of the American Chemical Society
Mass Spectrometry Characterization of Peroxycarboxylic Acids as Proxies for Reactive Oxygen Species and Highly Oxygenated Molecules in Atmospheric Aerosols.
SS Steimer, I Kourtchev, M Kalberer
– Anal Chem
Detection and identification of Criegee intermediates from the ozonolysis of biogenic and anthropogenic VOCs: comparison between experimental measurements and theoretical calculations
C Giorio, SJ Campbell, M Bruschi, AT Archibald, M Kalberer
– Faraday Discussions
Measurement of the Raman spectra and hygroscopicity of four pharmaceutical aerosols as they travel from pressurised metered dose inhalers (pMDI) to a model lung
N Davidson, H-J Tong, M Kalberer, PC Seville, AD Ward, MK Kuimova, FD Pope
– Int J Pharm
Heterogeneous reaction of ClONO2 with TiO2 and SiO2 aerosol particles: implications for stratospheric particle injection for climate engineering
M Tang, J Keeble, PJ Telford, FD Pope, P Braesicke, PT Griffiths, NL Abraham, J McGregor, IM Watson, RA Cox, JA Pyle, M Kalberer
– Atmospheric Chemistry and Physics
Dynamic viscosity mapping of the oxidation of squalene aerosol particles.
A Athanasiadis, C Fitzgerald, NM Davidson, C Giorio, SW Botchway, AD Ward, M Kalberer, FD Pope, MK Kuimova
– Physical chemistry chemical physics : PCCP
Enhanced Volatile Organic Compounds emissions and organic aerosol mass increase the oligomer content of atmospheric aerosols
I Kourtchev, C Giorio, A Manninen, E Wilson, B Mahon, J Aalto, M Kajos, D Venables, T Ruuskanen, J Levula, M Loponen, S Connors, N Harris, D Zhao, A Kiendler-Scharr, T Mentel, Y Rudich, M Hallquist, J-F Doussin, W Maenhaut, J Bäck, T Petäjä, J Wenger, M Kulmala, M Kalberer
– Scientific reports
An automated online instrument to quantify aerosol-bound reactive oxygen species (ROS) for ambient measurement and health-relevant aerosol studies
FPH Wragg, SJ Fuller, R Freshwater, DC Green, FJ Kelly, M Kalberer
– Atmospheric Measurement Techniques
Molecular composition of organic aerosols in central Amazonia: an ultra-high-resolution mass spectrometry study
I Kourtchev, RHM Godoi, S Connors, JG Levine, AT Archibald, AFL Godoi, SL Paralovo, CGG Barbosa, RAF Souza, AO Manzi, R Seco, S Sjostedt, JH Park, A Guenther, S Kim, J Smith, ST Martin, M Kalberer
– Atmospheric Chemistry and Physics
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Research Group

Research Interest Group

Telephone number

01223 336487 (shared)
36392 (shared)

Email address