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Dr Marco Di Antonio

Marco received his BSc in Organic Chemistry from University of Pavia in 2007 and a Ph.D in Pharmaceutical Sciences from University of Padua in 2011. During his Ph.D. he worked under the supervision of Prof. Manlio Palumbo and Prof. Mauro Freccero, gaining an extensive experience on the generation of reactive electrophilic species under physiological conditions as well as on G-quadruplex selective targeting by small molecule-ligands.

Following his Ph.D. he moved to Cambridge where he his currently a Post-Doctoral Research Associate in the Balasubramanian's group. Marco is investigating the role of G-quadruplex DNA and RNA secondary structures in biological processes important for diseases progression, with particular focus on cancer. His research interests spam from the generation of novel ligand to probe selectively G-quadruplex structures to the establishment of novel chemical-biology approaches to identify and investigate the biology of these secondary structures in human cells.

Marco has recently contributed to the generation of the first selective RNA G-quadruplex ligand, demonstrating the existence of RNA G-quadruplex in human cells for the first time. He has also been awarded a BBSRC research grant as co-investigator with Prof. Balasubramanian and guest-edited a special issue for the journal "Current Organic Chemisty".

Publications

CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours
H Xu, M Di Antonio, S McKinney, V Mathew, B Ho, NJ O'Neil, ND Santos, J Silvester, V Wei, J Garcia, F Kabeer, D Lai, P Soriano, J Banáth, DS Chiu, D Yap, DD Le, FB Ye, A Zhang, K Thu, J Soong, S-C Lin, AHC Tsai, T Osako, T Algara, DN Saunders, J Wong, J Xian, MB Bally, JD Brenton, GW Brown, SP Shah, D Cescon, TW Mak, C Caldas, PC Stirling, P Hieter, S Balasubramanian, S Aparicio
– Nature Communications
(2017)
8,
14432
Proximity-Induced H-Aggregation of Cyanine Dyes on DNA-Duplexes.
F Nicoli, MK Roos, EA Hemmig, M Di Antonio, R de Vivie-Riedle, T Liedl
– The journal of physical chemistry. A
(2016)
120,
9941
G-quadruplex structures mark human regulatory chromatin.
R Hänsel-Hertsch, D Beraldi, SV Lensing, G Marsico, K Zyner, A Parry, M Di Antonio, J Pike, H Kimura, M Narita, D Tannahill, S Balasubramanian
– Nature Genetics
(2016)
48,
1267
High-throughput sequencing of DNA G-quadruplex structures in the human genome
VS Chambers, G Marsico, JM Boutell, M Di Antonio, GP Smith, S Balasubramanian
– Nature Biotechnology
(2015)
33,
877
G-quadruplex ligands exhibit differential G-tetrad selectivity
DD Le, M Di Antonio, LKM Chan, S Balasubramanian
– Chemical communications (Cambridge, England)
(2015)
51,
8048
Dual Binding of an Antibody and a Small Molecule Increases the Stability of TERRA G-Quadruplex
PM Yangyuoru, M Di Antonio, C Ghimire, G Biffi, S Balasubramanian, H Mao
– Angewandte Chemie (Weinheim an der Bergstrasse, Germany)
(2015)
127,
924
Dual binding of an antibody and a small molecule increases the stability of TERRA G-quadruplex.
PM Yangyuoru, M Di Antonio, C Ghimire, G Biffi, S Balasubramanian, H Mao
– Angew Chem Int Ed Engl
(2015)
54,
910
Reprogramming the Mechanism of Action of Chlorambucil by Coupling to a G-Quadruplex Ligand
M Di Antonio, KIE McLuckie, S Balasubramanian
– Journal of the American Chemical Society
(2014)
136,
5860
Quinone Methides Generation: Applications in Chemical Biology
M Di Antonio
– Current Organic Chemistry
(2014)
18,
2
Visualization and selective chemical targeting of RNA G-quadruplex structures in the cytoplasm of human cells.
G Biffi, M Di Antonio, D Tannahill, S Balasubramanian
– Nature Chemistry
(2014)
6,
75
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Research Group

Telephone number

01223 762933 (shared)

Email address

md530@cam.ac.uk