Marco received his BSc in Organic Chemistry from University of Pavia in 2007 and a Ph.D in Pharmaceutical Sciences from University of Padua in 2011. During his Ph.D. he worked under the supervision of Prof. Manlio Palumbo and Prof. Mauro Freccero, gaining an extensive experience on the generation of reactive electrophilic species under physiological conditions as well as on G-quadruplex selective targeting by small molecule-ligands.
Following his Ph.D. he moved to Cambridge where he his currently a Post-Doctoral Research Associate in the Balasubramanian's group. Marco is investigating the role of G-quadruplex DNA and RNA secondary structures in biological processes important for diseases progression, with particular focus on cancer. His research interests spam from the generation of novel ligand to probe selectively G-quadruplex structures to the establishment of novel chemical-biology approaches to identify and investigate the biology of these secondary structures in human cells.
Marco has recently contributed to the generation of the first selective RNA G-quadruplex ligand, demonstrating the existence of RNA G-quadruplex in human cells for the first time. He has also been awarded a BBSRC research grant as co-investigator with Prof. Balasubramanian and guest-edited a special issue for the journal "Current Organic Chemisty".
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