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Dr Claudio Battilocchio

Portrait of cb700

Claudio is a Research Associate at Homerton College, working in the group of Prof Steven Ley on a collaborative programme with Syngenta (since December 2015). He is also a Postdoc Mentor in the Department of Chemistry.

He obtained his degree in Medicinal Chemistry in 2008, from "La Sapienza" (University of Rome). He was then awarded a position of research assistant to develop new antimycobacterial agents (Cariplo fellowship). In 2009, he started his PhD studies under the supervision of Prof. Mariangela Biava, working on the design and development of novel nitric oxide donors hybrids (Rottapharm fellowship). In 2011, Claudio joined the ITC (Innovative Technology Centre) at the University of Cambridge, working under the supervision of Dr. Ian R. Baxendale and Prof. Steven V. Ley on the application of flow technologies for the synthesis of SR48692 (Meclinertant) and on the flow synthesis of C2-symmetric chiral ligands. He was then appointed as postdoctoral research associate in Prof. Steven V. Ley group, working on the Open Innovation Programme with Pfizer.

Claudio has been involved in a series of successful Knowlegde Transfer Programmes with Industry, as part of the Ley group.

 

 

Research Interests

Claudio is interested in the application of enabling technologies to bridge academia and industry.

In particular, these are the main areas of interest: 

  • Sustainable chemistry using enabling technologies
  • Reactive intermediates using flow chemistry
  • New enabling tools for chemical synthesis

Publications

Recent publications:

36) Lima F., Kabeshov M.A., Tran D.N., Battilocchio C., Sedelmeier J, Sedelmeier G., Schenckel B., Ley S.V. Visible light activation of boronic esters enables efficient photoredox C(sp2)-C(sp3) cross-couplings in flow, Angew. Chem. Int. Ed., 2016, 55, 14085 –14089.

35) Poh J.S., Lau S.H., Dykes I.G., Tran D.N., Battilocchio C., Ley S.V. A multicomponent approach to the preparation of homoallylic alcohols Chem Sci, 2016, 7, 6803-6807.

34) Movsisyan M., Delbeke E.I.P., Berton J.K.E.T., Battilocchio C., Ley S.V., Stevens C.V. Taming hazardous chemistry by continuous flow technology, ChemSocRev, 2016, 45, 4892-4928 .

33) Battilocchio C.*, Feist F., Hafner A., Simon M., Tran D.N., Allwood D.M., Blakemore D.C., Ley S.V.* Iterative reactions of transient boronic acids enable sequential C-C bond formation, Nature Chemistry, 2016, 8, 360–367.

32) Ouchi T., R.J.Mutton, Rojas V., Fitzpatrick D.E., Cork D.G., Battilocchio C.*, Ley S.V.* Solvent-free continuous operations using small footprint reactors: a key approach for process intensification ACS Sust.Chem.Eng. 2016, 4, 1912-1916.

31) Fitzpatrick D.E., Battilocchio C., Ley S.V. Enabling technologies for the future of chemical synthesis, ACS Central. Science2016, 2 (3), 131–138.

30) Fitzpatrick D.E., Battilocchio C., Ley S.V. A Novel Internet-Based Reaction Monitoring, Control and Autonomous Self-Optimization Platform for Chemical Synthesis, Org. Process Res. Dev. 2016, 20, 386–394.

29) Briggs M.E., Slater A.G., Lunt N., Jiang S., Little M.A., Greenaway R.L., Hasell T., Battilocchio C., Ley S.V., Cooper A.I.  Dynamic flow synthesis of porous organic cages, Chem. Comm., 2015, 51, 17390-17393

28) Ley S.V., Fitzpatrick D.E., Myers R.M., Battilocchio C., Ingham R.J. Machine Assisted Organic Synthesis, Angew. Chem. Int. Ed., 2015, 54(35), 10122–10136.

27) Poh J.S., Tran D.N., Battilocchio C., Hawkins J.M., Ley S.V., A versatile room temperature route to di- and tri-substituted allenes via flow generated diazo compounds Angew. Chem. Int. Ed., 2015, 127(27), 8031–8034.

 

 

 

Publications

Continuous flow hydration of pyrazine-2-carbonitrile in a manganese dioxide column reactor
C Battilocchio, SH Lau, JM Hawkins, SV Ley
– Organic Syntheses
94,
34
Rapid Asymmetric Synthesis of Disubstituted Allenes by Coupling of Flow-Generated Diazo Compounds and Propargylated Amines
J-S Poh, S Makai, T von Keutz, DN Tran, C Battilocchio, P Pasau, SV Ley
– Angewandte Chemie International Edition (English)
(2017)
56,
1864
Rapid Asymmetric Synthesis of Disubstituted Allenes by Coupling of Flow-Generated Diazo Compounds and Propargylated Amines
J-S Poh, S Makai, T von Keutz, DN Tran, C Battilocchio, P Pasau, SV Ley
– Angewandte Chemie
(2017)
129,
1890
Visible Light Activation of Boronic Esters Enables Efficient Photoredox C(sp 2 )-C(sp 3 ) Cross-Couplings in Flow
F Lima, MA Kabeshov, DN Tran, C Battilocchio, J Sedelmeier, G Sedelmeier, B Schenkel, SV Ley
– Angewandte Chemie
(2016)
128,
14291
Visible Light Activation of Boronic Esters Enables Efficient Photoredox C(sp(2) )-C(sp(3) ) Cross-Couplings in Flow.
F Lima, MA Kabeshov, DN Tran, C Battilocchio, J Sedelmeier, G Sedelmeier, B Schenkel, SV Ley
– Angew Chem Int Ed Engl
(2016)
55,
14085
Taming hazardous chemistry by continuous flow technology
M Movsisyan, EIP Delbeke, JKET Berton, C Battilocchio, SV Ley, CV Stevens
– Chemical Society reviews
(2016)
45,
4892
Solvent-Free Continuous Operations Using Small Footprint Reactors: A Key Approach for Process Intensification
T Ouchi, RJ Mutton, V Rojas, DE Fitzpatrick, DG Cork, C Battilocchio, SV Ley
– ACS Sustainable Chemistry and Engineering
(2016)
4,
1912
Solvent-Free Continuous Operations Using Small Footprint Reactors: A Key Approach for Process Intensification
T Ouchi, RJ Mutton, V Rojas, DE Fitzpatrick, DG Cork, C Battilocchio, SV Ley
– ACS Sustainable Chemistry & Engineering
(2016)
4,
1912
Iterative reactions of transient boronic acids enable sequential C-C bond formation.
C Battilocchio, F Feist, A Hafner, M Simon, DN Tran, DM Allwood, DC Blakemore, SV Ley
– Nature Chemistry
(2016)
8,
360
Enabling Technologies for the Future of Chemical Synthesis.
DE Fitzpatrick, C Battilocchio, SV Ley
– ACS central science
(2016)
2,
131
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