I received my B.Sc (Hons) from the National University of Ireland, Galway (1998) and my Ph.D (2002) from the same university under the direction of Prof. Richard Butler. My Ph.D work focused on the synthetic and mechanistic aspects of the Huisgen cycloaddition reaction with an emphasis on the role of water as a reaction solvent. I then moved to an industrial position with GlaxoSmithKline and returned to academia as a postdoctoral fellow (2004) to the group of Prof Pat Guiry at University College Dublin. In 2006 I moved to a postdoctoral position at the University of Cambridge in the group of Dr Martin Smith. In 2008 I moved to my current position in the group of Prof. Chris Abell at the University of Cambridge where I am a Senior Research Associate. I currently co-supervise the Abell research group.
I am interested in applying fragment-based drug discovery approaches to targeting metalloproteins. I am current applying this methodology to targeting the cytochrome P450's from M. tuberculosis, and the current focus is on CYP121, CYP142 and CYP126. A further area of research that I am interested in is the application of water as a reaction solvent to organic synthesis. I am interested in looking at the mechanistic aspects on how reactions behave when they are carried out in an aqueous medium.
Part III Project Supervision
- Previous Projects
Project 1 - 'Targeting CYP121 of Mycobacterium tuberculosis using a fragment linking approach'
Project 2 - 'Development of novel fragment scaffolds using cycloaddition methodologies'
Project 3 - 'A fragment elaboration project targeting CYP142 from Mycobacterium tuberculosis'
Undergraduate Chemistry Supervisions
- Part III - Medicinal Chemistry course - M10
- Part II - Biological Catalysis - B3
- "Organic Synthesis in Water: Kinetics, Synthesis and Mechanism" - Postgraduate Lecture Course, Michaelmas Term
- ''Fragment Based Drug Discovery'' - Postgraduate Lecture Course, Easter Term
- Head of Class - Part II Organic Chemistry Laboratory
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