Fixed-term: The funds for this post are available until 30 June 2016 in the first instance.
Applications are invited for a Postdoctoral Research Associate position to join the group of Professor Robert Glen as part of a significant interdisciplinary effort to understand the underlying biology of Pulmonary Arterial Hypertension. The post is funded by the Medical Research Council. The work will be performed in the Unilever Centre for Molecular Science Informatics in the Department of Chemistry.
The research associate will contribute to the programme by simulating proteins underlying the disease as well as designing peptides and small molecules which will be synthesised and evaluated as pharmacological probes in a variety of biological assays and clinical settings.
The successful candidate will work on the following priority application areas:
1. Simulation of Bone Morphogenic Proteins and their protein-protein interactions using the latest GPU-enabled Molecular Dynamics simulation codes and High Performance Computers.
2. The Design of peptides and small molecules and their analogues.
3. Interpretation and re-design of analogues based on the deduction of Structure-Activity Relationships.
The successful candidate will have a first degree in a science discipline and have (or be about to obtain) a PhD with extensive experience of computational molecular dynamics with a strong protein simulation bias. The ability to work with clinicians, biologists and pharmacologists and gain a working knowledge of the underlying biology will be vital.
Applicants should also have significant programming skills (typically C++, Java, Scripting) to enable the modification of programs, formatting of data and analysis of results. Familiarity with Molecular Dynamics codes (Gromacs, Amber, Charmm) is a prerequisite. Molecular Modelling/Cheminformatics and Structure-Based design skills would be beneficial. Candidates are expected to demonstrate good IT, problem solving and communication skills, the ability to work within a team and to manage their own workload.
Applications should include a CV and covering letter, publications list, names and contact details for three professional referees, and a completed form CHRIS/6 Parts I and III (downloadable from http://www.admin.cam.ac.uk/offices/hr/forms/chris6/) and should be addressed to Susan Begg (email: smb28@cam.ac.uk), Department of Chemistry, Lensfield Road, Cambridge CB2 1EW.
Please quote reference MA01677 on your application and in any correspondence about this vacancy.
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