Department of Chemistry

Balasubramanian Group

Publications

2013

  1. Oxidative Bisulfite sequencing of 5-methylcytosine and 5-hydroxymethlcytosine
    Michael J Booth, Toby W B Ost, Dario Beraldi, Neil M Bell, Miguel Branco, Wolf Reik and Shankar Balasubramanian
    Nature Protocols, 8 1841-1851 (2013)
    DOI: 10.1038/nprot.2013.115
    PDF

  1. Light-mediated in cell downregulation of G-quadruplex-containing genes using a photo-caged ligand
    Pierre Murat, Michael V. Gormally, Debbie Sanders, Marco Di Antonio and Shankar Balasubramanian
    Chem. Commun., 2013, 49 (76), 8453 - 8455
    DOI: 10.1039/C3CC44737E
    PDF

  1. G-quadruplex DNA as a Molecular Target for Induced Synthetic Lethality in Cancer Cells
    Keith I. .E. McLuckie, Marco Di Antonio, H Zecchini, J Xian, Carlos Caldas, B Fillippo Krippendorff, David Tannahill, Christopher Lowe and Shankar Balasubramanian
    J. Am. Chem. Soc., 2013, 135 (26), pp 9640–9643
    DOI: 10.1021/ja404868t
    PDF

  1. G-quadruplex structures are stable and detectable in human genomic DNA
    E Yi Ni Lam, D Beraldi, D Tannahill and S Balasubramanian
    Nature Communications, 4, 1796 (2013)
    DOI: doi:10.1038/ncomms2792
    PDF

  1. Down-regulation of androgen receptor transcription by promoter G-quadruplex stabilization as a potential alternative treatment for castrate-resistant prostate cancer
    T Mitchell, A Ramos-Montoya, M Di Antonio, P Murat, S Ohnmacht, M Micco, S Jurmeister, L Fryer, S Balasubramanian, S Neidle and D E Neal
    Biochemistry, 52 (8) 1429-36 (2013)
    DOI: doi: 10.1021/bi301349c
    PDF
  2. Genome-wide mapping of FOXM1 binding reveals co binding with estrogen receptor alpha in breast cancer cells
    D A Sanders, C S Ross-Innes, D Beraldi, J S Carroll and S Balasubramanian
    Genome Biology, 14:R6 (2013) doi:10.1186/gb-2013-14-1-r6
    PDF
  3. Quantitative visualization of DNA G-quadruplex structures in human cells
    G Biffi, D Tannahill, J McCafferty and S Balasubramanian
    Nature Chemistry, 5 182-186 (2013)
    DOI: 10.1038/nchem.1548
    PDF
  4. An Acetylene-Bridged 6,8-Purine Dimer as a Fluorescent Switch-On Probe for Parallel G-Quadruplexes
    M Nikan, M Di Antonio, K Abecassis, K McLuckie and S Balasubramanian
    Angew. Chem. Int. Ed, 52 (5) 1428-1431 (2013)
    DOI: 10.1002/anie.201207075
    PDF

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2012

  1. An RNA Hairpin to G-Quadruplex Conformational Transition
    A Bugaut, P Murat and S Balasubramanian
    J Am Chem Soc, 134 (49) 19953-19956 (2012)
    DOI: 10.1021/ja308665g
    PDF
  2. The Kinetics and Folding Pathways of Intramolecular G-Quadruplex Nucleic Acids
    A Zhang and S Balasubramanian
    J Am Chem Soc, 134 (46) 19297-19308 (2012)
    DOI: 10.1021/ja309851t
    PDF
  3. Selective RNA Versus DNA G-Quadruplex Targeting by In Situ Click Chemistry
    M Di Antonio, G Biffi, A Mariani, E Raiber, R Rodriguez and S Balasubramanian
    Angew. Chem. Int. Ed, 51 (44), 11073-11078 (2012)
    DOI: 10.1002/anie.201206281
    PDF
  4. Pyridostatin analogues promote telomere dysfunction and long-term growth inhibition in human cancer cells
    S Müller, DA Sanders, M Di Antonio, S Matsis, JF Riou, R Rodriguez and S Balasubramanian
    Org Biomol Chem, 10,6537-6546 (2012)
    DOI: 10.1039/C2OB25830G
    PDF
  5. Genome-wide distribution of 5-formylcytosine in embryonic stem cells is associated with transcription and depends on thymine DNA glycosylase
    E Raiber, D Beraldi, G Ficz, H Burgess, M R Branco, P Murat, D Oxley, M J Booth, W Reik and S Balasubramanian
    Genome Biology, 13:R69 (2012)
    DOI: 10.1186/gb-2012-13-8-r69
    PDF
  6. An Intramolecular G-Quadruplex Structure Is Required for Binding of Telomeric Repeat-Containing RNA to the Telomeric Protein TRF2
    G Biffi, D Tannahill and S Balasubramanian
    J Am Chem Soc., 134 (29), 11974–11976 (2012)
    DOI: 10.1021/ja305734x
    PDF
  7. 5′-UTR RNA G-quadruplexes: translation regulation and targeting
    A Bugaut and S Balasubramanian
    Nucleic Acids Research, 40 (11), 4727-4741 (2012)
    DOI: 10.1093/nar/gks068
    PDF
  8. Quantitative Sequencing of 5-Methylcytosine and 5-Hydroxymethylcytosine at Single-Base Resolution
    M J Booth, M R Branco, G Ficz, D Oxley, F Krueger, W Reik and S Balasubramanian
    Science, 336 934-7 (2012)
    DOI: 10.1126/science.1220671
    PDF
  9. Experimental Approaches to Identify Cellular G-quadruplex Structures and Functions
    M Di Antonio, R Rodriguez and S Balasubramanian
    Methods, 57 (1), 84-92 (2012)
    DOI: 10.1016/j.ymeth.2012.01.008
    PDF
  10. Comparative Structural Effects of HIV-1 Gag and Nucleocapsid Proteins in Binding to and Unwinding of the Viral RNA Packaging Signal
    N M Bell, J C Kenyon, S Balasubramanian and A M L Lever
    Biochemistry, 51 (15) 3162-9 (2012)
    DOI: 10.1093/nar/gks068
    PDF
  11. Small-molecule–induced DNA damage identifies alternative DNA structures in human genes
    R Rodriguez, K M Miller, J V Forment, C R Bradshaw, M Nikan, S Britton, T Oelschlaegel, B Xhemalce, S Balasubramanian and S P Jackson
    Nat. Chem. Biol., 8 (3), 301-10 (2012)
    DOI: 10.1038/nchembio.780
    PDF
  12. FANCJ coordinates two pathways that maintain epigenetic stability at G-quadruplex DNA
    P Sarkies, P Murat, L G Phillips, K J Patel, S Balasubramanian and J E Sale
    Nucleic Acids Research, 40 (4), 1485-98 (2012)
    DOI: 10.1093/nar/gkr882
    PDF
  13. A non-canonical DNA structure is a binding motif for the transcription factor SP1 in vitro
    E Raiber, R Kranaster, E Lam, M Nikan and S Balasubramanian
    Nucleic Acids Research,40 (4), 1499-508 (2012)
    DOI: 10.1093/nar/gkr882
    PDF
  14. Demonstration of Ligand Decoration, and Ligand-Induced Perturbation, of G-Quadruplexes in a Plasmid Using Atomic Force Microscopy
    I Mela, R Kranaster, R M Henderso, S Balasubramanian and J M Edwardson
    Biochemistry, 51 (2), 578–585 (2012)
    DOI: 10.1021/bi201600g
    PDF
  15. Synthesis of Bis-indole Carboxamides as G-Quadruplex Stabilizing and Inducing Ligands
    J Dash; R N Das, N Hegde, G D Pantoş, P Shirude and S Balasubramanian
    Chem. European Journal, 18 (2), 554-64 (2012)
    DOI: 10.1002/chem.201102556
    PDF

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2011

  1. Decoding genomes at high speed: implications for science and medicine
    S Balasubramanian
    Angew. Chem. Int. Ed, 50 (52), 12406-12410 (2011)
    DOI: 10.1002/anie.201106707 (2011)
    PDF
  2. A single-molecule platform for investigation of interactions between G-quadruplexes and small-molecule ligands
    D Koirala, S Dhakal, B Ashbridge, Y Sannohe, R Rodriguez, H Sugiyama, S Balasubramanian and H Mao
    Nature Chemistry, 3, 782-787 (2011)
    DOI: 10.1038/nchem.1126
    PDF
  3. The transcription factor FOXM1 is a cellular target of the natural product thiostrepton
    N S Hegde, D A Sanders, R Rodriguez and S Balasubramanian
    Nature Chemistry, 3, 725-731 (2011)
    DOI: 10.1038/nchem.1114
    PDF
  4. A LIN28-Dependent Structural Change in pre-let-7g Directly Inhibits Dicer Processing
    H L Lightfoot, A Bugaut, J Armisen, N J Lehrbach, E A Miska and S Balasubramanian
    Biochemistry, 50, 7514-7521 (2011)
    DOI: 10.1021/bi200851d
    PDF
  5. A Sequence-Independent Analysis of the Loop Length Dependence of Intramolecular RNA G-Quadruplex Stability and Topology
    A Zhang, A Bugaut and S Balasubramanian
    Biochemistry, 50, 7251-7258 (2011)
    DOI: 10.1021/bi200805j
    PDF
  6. Sequencing nucleic acids: from chemistry to medicine
    S Balasubramanian
    RSC Chem. Commun., 47 (26), 7281-7286 (2011)
    DOI:10.1039/c1cc11078k Highlight
    PDF
  7. Targeting G‐quadruplexes in gene promoters: a novel anticancer strategy?
    S Balasubramanian, L H Hurley and S Neidle
    Nature Reviews Drug Discovery, 10, 261-275 (2011)
    DOI:10.1038/nrd3428
    PDF
  8. Rudimentary G-quadruplex-based telomere capping in Saccharomyces cerevisiae
    J S Smith, Q Chen, L A Yatsunyk, J M Nicoludis, M S Garcia, R Kranaster, S Balasubramanian, D Monchaud, M Teulade-Fichou, L Abramowitz, D C Schultz and F B Johnson
    Nature Structural & Molecular Biology, 18, 478-485 (2011)
    DOI: 10.1038/nsmb.2033
    PDF
  9. Synthesis and Binding Studies of Novel Diethynyl-pyridine Amides with Genomic Promoter DNA G-quadruplexes
    J Dash, ZA E Waller, G D Pantos and S Balasubramanian
    Chem. European Journal, 17, 4571-4581 (2011)
    DOI: 10.1002/chem.201003157
    PDF
  10. G-Quadruplex-Binding Benzo[a]phenoxazines Down-Regulate c-KIT Expression in Human Gastric Carcinoma Cells
    K I E McLuckie, Z A E Waller, D A Sanders,D Alves,R Rodriguez, J Dash, G J McKenzie, A R Venkitaraman and S Balasubramanian
    J. Am. Chem. Soc. 133,2658–2663 (2011)
    DOI: 10.1021/ja109474c
    PDF

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2010

  1. Small-molecule-mediated G-quadruplex isolation from human cells
    S Muller, S Kumari, R Rodriguez and S Balasubramanian
    Nature Chemistry, 2, 1095-1098 (2010)
    DOI: 10.1038/NCHEM.842
    PDF
  2. Targeting the c-Kit Promoter G-quadruplexes with 6-Substituted Indenoisoquinolines
    M Bejugam, M Gunaratnam, S Mueller, D A Sanders, S Sewitz, J A Fletcher, S Neidle and S Balasubramanian
    ACS Med. Chem. Lett. 1, 306–310 (2010)
    DOI: 10.1021/ml100062z
    PDF
  3. Distinct functions of maternal and somatic Pat1 protein paralogs
    A Marnef, M Maldonado, A Bugaut, S Balasubramanian, M Kress, D Weil and N Standart
    RNA, 16, 2094–2107 (2010)
    DOI: 10.1261/rna.2295410
    PDF
  4. The BCL-2 50 Untranslated Region Contains an RNA G-Quadruplex-Forming Motif that Modulates Protein Expression
    R Shahid, A Bugaut and S Balasubramanian
    Biochemistry, 49, 8300–8306 (2010)
    DOI: 10.1021/bi100957h
    PDF
  5. Small Molecule-mediated inhibition of translation by targeting a native RNA G-quadruplex
    A Bugaut, R Rodriguez, S-T D Hsu and S Balasubramanian
    Org. Biomol. Chem., 8, 2771-2776 (2010)
    DOI: 10.1039/c002418j
    PDF
  6. RNA Conformation in Catalytically Active Human Telomerase
    J A Yeoman, A Orte, B Ashbridge, D Klenerman and S Balasubramanian
    J. Am. Chem. Soc., 132, 2852-2853 (2010)
    DOI: 10.1021/ja909383n
    PDF
  7. Ensemble and single molecule FRET analysis of the structure and unfolding kinetics of the c-kit promoter quadruplexes
    A Fegan, P S Shirude, L Ying and S Balasubramanian
    Chem.Commun. 46,946-948 (2010)
    DOI: 10.1039/b920680a
    PDF

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2009

  1. Single-Molecule Analysis of the Human Telomerase RNA·Dyskerin Interaction and the Effect of Dyskeratosis Congenita Mutations
    B Ashbridge, A Orte, J A Yeoman, M Kirwan, T Vulliamy, I Dokal, D Klenerman and S Balasubramanian
    Biochemistry, 48, 10858-10865 (2009)
    DOI: 10.1021/bi901373e
    PDF
  2. Genome-wide analysis of a G-quadruplex-specific single-chain antibody that regulates gene expression
    H Fernando, S Sewitz, J Darot, S Tavaré, J L Huppert and S Balasubramanian
    Nucleic Acids Research, 37, 6716-6722 (2009)
    DOI: 10.1093/nar/gkp740
    PDF
  3. LIN-28 and the poly(U) polymerase PUP-2 regulate let-7 microRNA processing in Caenorhabditis elegans
    N J Lehrbach, J Armisen, H L Lightfoot, K J Murfitt, A Bugaut, S Balasubramanian and E A Miska
    Nature Structural & Molecular Biology, 16, 1016-1020 (2009)
    DOI:10.1038/nsmb.1675
    PDF
  4. A G-Rich Sequence within the c-kit Oncogene Promoter Forms a Parallel G-Quadruplex Having Asymmetric G-Tetrad Dynamics
    S T Hsu, P Varnai, A Bugaut, A P Reszka, S Neidle and S Balasubramanian
    J. Am. Chem. Soc., 131, 13399-409 (2009)
    DOI: 10.1021/ja904007p
    PDF
  5. G-quadruplex DNA bound by a synthetic ligand is highly dynamic
    P V Jena, P S Shirude, B Okumus, K Laxmi-Reddy, F Godde, I Huc, S Balasubramanian and T Ha
    J. Am. Chem. Soc., 131, 12522-3 (2009)
    DOI: 10.1021/ja903408r
    PDF
  6. A small molecule that disrupts G-quadruplex DNA structure and enhances gene expression
    Z A Waller, S A Sewitz, S T Hsu and S Balasubramanian
    J. Am. Chem. Soc., 131, 12628-33 (2009)
    DOI: 10.1021/ja901892u
    PDF
  7. G-quadruplex nucleic acids as therapeutic targets
    S Balasubramanian and S Neidle
    Current Opinion in Chemical Biology, 13, 345-353 (2009)
    DOI: 10.1016/j.cbpa.2009.04.637
    PDF
  8. Controlled-folding of a small molecule modulates DNA G-quadruplex recognition
    S Muller, G Dan Pantos, R Rodriguez and S Balasubramanian
    Chem.Commun., 80-82 (2009)
    DOI: b816861.j
    PDF
  9. Recognition and discrimination of DNA quadruplexes by acridine-peptide conjugates
    J E Redman, J M Granadino-Roldán, J A Schouten, S Ladame, A P Reszka, S Neidle and S Balasubramanian
    Org. Biomol. Chem., 7, 76-84 (2009)
    DOI: b814682a
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2008

  1. FANCJ Is a Structure-specific DNA Helicase Associated with the Maintenance of Genomic G/C Tracts
    T B C London, L J Barber, G Mosedale, G P Kelly, S Balasubramanian, I D Hickson, S J Boulton and K Hiom
    J. Biol. Chem., 283, 36132-36139 (2008)
    DOI: 10.1074/jbc.M808152200
    PDF
  2. Position and Stability Are Determining Factors for Translation Repression by an RNA G-Quadruplex-Forming Sequence within the 5' UTR of the NRAS Proto-oncogene
    S Kumari, A Bugaut and S Balasubramanian
    Biochemistry, 47, 12664-12669 (2008)
    DOI: 10.1038/nchembio864
    PDF
  3. Diarylethynyl Amides That Recognize the Parallel Conformation of Genomic Promoter DNA G-Quadruplexes
    J Dash, P S Shirude, S-T D Hsu and S Balasubramanian
    J. Am. Chem. Soc., 130, 15950-15956 (2008)
    DOI: 10.1021/ja8046552
    PDF
  4. A Novel Small Molecule That Alters Shelterin Integrity and Triggers a DNA-Damage Response at Telomeres
    R Rodriguez, S Muller, J A Yeoman, C Trentesaux, J-F Riou and S Balasubramanian
    J. Am. Chem. Soc., 130, 15758-15759 (2008)
    DOI: 10.1021/ja805615w
    PDF
  5. Accurate whole human genome sequencing using reversible terminator chemistry
    D R Bentley, S Balasubramanian, H P Swerdlow et al
    Nature, 456, 53-59 (2008)
    DOI: 10.1038/nature07517
    PDF
  6. G-quadruplexes: the beginning and end of UTRs
    J L Huppert, A Bugaut, S Kumari and S Balasubramanian
    Nucleic Acids Res., 36, 6260-6268 (2008)
    DOI: 10.1093/nar/gkn511
    PDF
  7. Selective Recognition of a DNA G-Quadruplex by an Engineered Antibody
    H Fernando, R Rodriguez and S Balasubramanian
    Biochemistry, 47, 9365-9371 (2008)
    DOI: 10.1021/bi800983u
    PDF
  8. Single molecule conformational analysis of DNA G-quadruplexes
    P S Shirude and S Balasubramanian
    Biochimie, 90, 1197-1206 (2008)
    DOI: 10.1039/b801465e
    PDF
  9. G-quadruplex recognition by bis-indole carboxamides
    J Dash, P S Shirude and S Balasubramanian
    Chem. Commun., 3055-3057 (2008)
    DOI: 10.1039/b806042h
    PDF
  10. Single molecule conformational analysis of the biologically relevant DNA G-quadruplex in the promoter of the proto-oncogene c-MYC
    P S Shirude, L Ying and S Balasubramanian
    Chem. Commun.,     2007-2009 (2008)
    DOI: 10.1039/b801465e
    PDF
  11. Rigid cyanine dye nucleic acid labels
    A Fegan, P S Shirude and S Balasubramanian
    Chem. Commun., 2004-2006 (2008)
    DOI: 10.1039/b801629a
    PDF
  12. Single-molecule analysis of human telomerase monomer
    D Alves, H Li, R Codrington, A Orte, X Ren, D Klenerman and S Balasubramanian
    Nature Chem.Biol., 4, 287-289 (2008)
    DOI: 10.1038/nchembio.82
    PDF
  13. Exploring the differential recognition of DNA G-quadruplex targets by small molecules using dynamic combinatorial chemistry
    A Bugaut, K Jantos, J-L Wietor, R Rodriguez, J K M Sanders and S Balasubramanian
    Angew. Chem. Int. Ed., 47, 2677-2680 (2008)
    DOI: 10.1002/anie.200705589
    PDF
  14. Triarylpyridines: a versatile small molecule scaffold for G-quadruplex recognition
    Z Waller, P Shirude, R Rodriguez and S Balasubramanian
    Chem. Commun., 1467-1469 (2008)
    DOI: 10.1039/b718854d
    PDF
  15. A Sequence-Independent Study of the Influence of Short Loop Lengths on the Stability and Topology of Intramolecular DNA G-Quadruplexes
    A Bugaut and S Balasubramanian
    Biochemistry, 47, 689-697 (2008)
    DOI: 10.1021/bi701873c
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2007

  1. Trisubstituted Isoalloxazines as a New Class of G-Quadruplex Binding Ligands: Small Molecule Regulation of c-kit Oncogene Expression
    M Bejugam, S Sewitz, P S Shirude, R Rodriguez, R Shahid and S Balasubramanian
    J. Am. Chem. Soc., 129, 12926-12927 (2007)
    DOI: 10.1021/ja075881p
    PDF
  2. Macrocyclic and Helical Oligoamides as a New Class of G-Quadruplex Ligands
    P S Shirude, E R Gillies, S Ladame, F Godde, K Shin-ya, I Huc and S Balasubramanian
    J. Am. Chem. Soc. 129, 11890-11891 (2007)
    DOI: 10.1021/ja073775h
    PDF
  3. Ligand-Driven G-Quadruplex Conformational Switching By Using an Unusual Mode of Interaction
    R Rodriguez, G Dan Pantos, D P N Goncalves, J K M Sanders and S Balasubramanian
    Angew. Chem. Int. Ed., 46, 5404-5407 (2007)
    DOI: 10.1002/anie.20060507
    PDF
  4. Single-Molecule Conformational Analysis of G-Quadruplex Formation in the Promoter DNA Duplex of the Proto-Oncogene C-Kit
    P S Shirude, B Okumus, L Ying, T Ha and S Balasubramanian
    J. Am. Chem. Soc., 129, 7484-7485 (2007)
    DOI: 10.1021/ja070497d
    PDF
  5. An RNA G-quadruplex in the 5' UTR of the NRAS proto-oncogene modulates translation
    S Kumari, A Bugaut, J L Huppert and S Balasubramanian
    Nature Chem. Biol., 3, 218-221 (2007)
    DOI: 10.1038/nchembio864
    PDF
  6. G-quadruplexes in promoters throughout the human genome
    J L Huppert and S Balasubramanian
    Nucleic Acids Res., 35, 2, 406-413 (2007)
    DOI: 10.1093/nar/gkm109
    PDF

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2006

  1. Tetramethylpryidiniumporphyrazines - a new class of G-quadruplex inducing and stabilising ligands
    D P Goncalves, R Rodriguez, S Balasubramanian and J K M Sanders
    Chem. Commun., 4685-4687 (2006)
  2. Discovery of G-quadruplex stabilizing ligands through direct ELISA of a one-bead-one-compound library
    J E Redman, S Ladame, A P Reszka, S Neidle and S Balasubramanian
    Org. Biomol. Chem., 4, 4364-4369 (2006)
  3. A Simple Nanomixer for Single-Molecule Kinetics Measurements
    S S White, S Balasubramanian, D Klenerman and L Ying
    Angew. Chem. Int. Ed., 45 7540-7543 (2006)
  4. Determination of the Fraction and Stoichiometry of Femtomolar Levels of Biomolecular Complexes in an Excess of Monomer Using Single-Molecule, Two-Color Coincidence Detection
    A Orte, R Clarke, S Balasubramanian and D Klenerman
    Anal. Chem., 78, 7707-7715 (2006)
  5. Structural Analysis of the Catalytic Core of Human Telomerase RNA by FRET and Molecular Modeling
    G Gavory, M F Symmons, Y Krishnan Ghosh, D Klenerman and S Balasubramanian
    Biochemistry, 45, 13304-13311 (2006)
  6. Oxazole-Based Peptide Macrocycles: A New Class of G-Quadruplex Binding Ligands
    K Jantos, R Rodriguez, S Ladame, P S Shirude and S Balasubramanian
    J. Am. Chem. Soc., 128, 13662-13663 (2006)
  7. Synthesis and G-quadruplex binding studies of new 4-N-methylpyridinium porphyrins
    D P N Goncalves, S Ladame, S Balasubramanian and J K M Sanders
    Org. Biomol. Chem., 4, 3337-3342 (2006)
  8. Investigating a quadruplex-ligand interaction by unfolding kinetics
    J J Green, S Ladame, L Ying, D Klenerman and S Balasubramanian
    J. Am. Chem. Soc., 126, 9809-9812 (2006)
  9. A Conserved Quadruplex Motif Located in a Transcription Activation Site of the Human c-kit Oncogene
    H Fernando, A P Reszka, J Huppert, S Ladame, S Rankin, A R Venkitaraman, S Neidle and S Balasubramanian
    Biochemistry, 45, 7854-7860 (2006)
  10. Analysis of Human Telomerase Activity and Function by Two Color Single Molecule Coincidence Fluorescence Spectroscopy
    X Ren, H Li, R W Clarke, D A Alves, L Ying, D Klenerman and S Balasubramanian
    J. Am. Chem. Soc., 128, 4992-5000 (2006)
  11. A Reversible pH-Driven DNA Nanoswitch Array
    D Liu, A Bruckbauer, C Abell, S Balasubramanian, D-J Kang, D Klenerman and D Zhou
    J. Am. Chem. Soc., 128, 2067-2071 (2006)
  12. Exploring the Recognition of Quadruplex DNA by an Engineered Cys2-His2 Zinc Finger Protein
    S Ladame, J A Schouten, J Roldan, J E Redman, S Neidle and S Balasubramanian
    Biochemistry, 45, 1393-1399 (2006)

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2000-2005

  1. DNA molecular motor driven micromechanical cantilever arrays
    W Shu, D Liu, M Watari, C K Riener, T Strunz, M E Welland, S Balasubramanian and R McKendry
    J. Am. Chem. Soc., 127, 17054-17060 (2005)
  2. PNA forms an i-motif
    Y Krishnan-Ghosh, E Stephens and S Balasubramanian
    Chem. Commun., 5278-5280 (2005)
  3. Targeting nucleic acid secondary structures with polyamides using an optimized dynamic combinatorial approach
    S Ladame, A Whitney and S Balasubramanian
    Angew. Chem. Intl. Ed., 44, 5736-5739 (2005)
  4. Putative DNA quadruplex formation within the human c-kit oncogene
    S Rankin, A P Reszka, J Huppert, M Zloh, G N Parkinson, A K Todd, S Ladame, S Balasubramanian and S Neidle
    J. Am. Chem. Soc., 127, 10584-10589 (2005)
  5. Dynamic Covalent Chemistry on Self-Templating PNA Oligomers: Formation of a Bimolecular PNA Quadruplex
    Y Krishnan-Ghosh, A Whitney and S Balasubramanian
    Chem. Commun., 3068-3070 (2005)
  6. Prevalence of quadruplexes in the human genome
    J L Huppert and S Balasubramanian
    Nucleic Acids Res., 33, 2908-2916 (2005)
  7. Solid-phase methods for the synthesis of cyanine dyes
    S Mason, J Hake, J Nairne, E J Cummins and S Balasubramanian
    J. Org. Chem., 70, 2939-2949 (2005)
  8. Loop-length dependent folding of G-quadruplexes
    P Hazel, J Huppert, S Balasubramanian and S Neidle
    J. Am. Chem. Soc., 126, 16405-16415 (2004)
  9. Individual molecules of dye-labeled DNA act as a reversible two-colour switch upon application of an electric field
    S S White, L Ying, S Balasubramanian and D Klenerman
    Angew. Chem. Intl. Ed., 43, 5926-5930 (2004)
  10. Inhibition of human telomerase activity by an engineered zinc finger protein that binds G-quadruplexes
    S D Patel, M Isalan, G Gavory, S Ladame, Y Choo and S Balasubramanian
    Biochemistry, 43, 13452-13458 (2004)
  11. Tetrapeptides induce selective recognition for G-quadruplexes when conjugated to a DNA-binding platform
    S Ladame, J A Schouten, J Stuart, J Roldan, S Neidle and S Balasubramanian
    Org. Biomol. Chem., 2, 2925-2931 (2004)
  12. Measuring Single Molecule Nucleic Acid Dynamics in Solution by Two-Color Filtered Ratiometric Fluorescence Correlation Spectroscopy
    H Li, X Ren, S Balasubramanian and D Klenerman
    Proc. Natl. Acad. Sci. USA, 101, 14425-14430 (2004)
  13. Formation of an Interlocked Quadruplex Dimer by d(GGGT)
    Y Krishnan-Ghosh, D Liu and S Balasubramanian
    J. Am. Chem. Soc., 125, 11009-11016 (2004)
  14. Studies on the chemical stability and synthetic utility of an oxazolidine linker for solid-phase chemistry
    A J Wills, M Cano and S Balasubramanian
    J. Org. Chem., 69, 5439-47 (2004)
  15. Molecule by molecule direct and quantitative counting of antibody complexes in solution
    H Li, L Ying, S Balasubramanian and D Klenerman
    Anal. Chem., 76, 4446-51 (2004)
  16. A PNA4 Quadruplex
    Y Krishnan-Ghosh, E Stephens and S Balasubramanian
    J. Am. Chem. Soc., 126, 5944-5945 (2004)
  17. Targeting the Single-Stranded Overhang of Telomeres with PNA Inhibits Cell Growth and Induces Apoptosis of Human Immortal Cells
    M A Shammas, X Liu, G Gavory, K D Raney, S Balasubramanian and R J Shmookler Reis
    Experimental Cell Research, 295, 204-214 (2004)
  18. Templated Ligand Assembly using G-quadruplex DNA and Dynamic Covalent Chemistry
    A Whitney, S Ladame and S Balasubramanian
    Angew. Chem. Intl. Ed., 43, 1143-1146 (2004)
  19. Studies on the Structure and Dynamics of the Human Telomeric Quadruplex by Single Molecule Fluorescence Resonance Energy Transfer
    L Ying, J J Green, H Li, D Klenerman and S Balasubramanian
    Proc. Natl. Acad. Sci. USA, 100, 14629-14634 (2003)
  20. A proton fuelled DNA nanomachine
    D Liu and S Balasubramanian
    Angew. Chem. Intl. Ed., 42, 5734-5736 (2003)
  21. Identification of a new RNA*RNA interaction site for human telomerase RNA (hTR): structural implications for hTR accumulation and a dyskeratosis congenital point mutation
    X Ren, G Gavory, H Li, L Ying, D Klenerman and S Balasubramanian
    Nucleic Acids Res., 31, 6509-6515 (2003)
  22. From the combinatorial chemistry boom to polymer-supported parallel chemistry: established technologies for drug discovery
    M Cano and S Balasubramanian
    Drugs of the Future, 28, 659-678 (2003)
  23. Recent Developments in Linker Design and Application
    A J Wills and S Balasubramanian
    Curr. Op. Chem. Biol., 7, 346-352 (2003)
  24. Dynamic Covalent Chemistry on Self-Templating Peptides: Formation of a Disulphide-linked ?-Hairpin Mimic
    Y Krishnan-Ghosh and S Balasubramanian
    Angew. Chem. Intl. Ed., 42, 2171-2173 (2003)
  25. G-Quadruplex-Specific Peptide-Hemicyanine Ligands by Partial Combinatorial Selection
    J A Schouten, S Ladame, S J Mason, M A Cooper and S Balasubramanian
    J. Am. Chem. Soc., 125, 5594-5595 (2003)
  26. Kinetics of Unfolding the Human Telomeric DNA Quadruplex using a PNA Trap
    J Green, L Ying, D Klenerman and S Balasubramanian
    J. Am. Chem. Soc., 125, 3763-3767 (2003)
  27. Ultrasensitive coincidence fluorescence detection of single DNA molecules
    H Li, L Ying, J J Green, S Balasubramanian and D Klenerman
    Anal. Chem., 75, 1664-1670 (2003)
  28. Site-Specific Cleavage of Human Telomerase RNA using PNA-Neocuproine*Zn(II) derivatives
    A Whitney, G Gavory and S Balasubramanian
    Chem. Commun. 36-37 (2003)
  29. PNA and oligonucleoide inhibitors of human telomerase
    G Gavory and S Balasubramanian
    Telomerases, Telomeres and Cancer Eds. G Krupp and R Parwaresch 67-80, Landes Bioscience: Austin (2003)
  30. Solid phase catch-activate and release synthesis of cyanine dyes
    S J Mason and S Balasubramanian
    Org. Lett., 4, 4261-62 (2002)
  31. Minimum length requirement of the alignment domain of human telomerase RNA to sustain catalytic activity in vitro
    G Gavory, M Farrow and S Balasubramanian
    Nucleic Acids Res., 30, 4470-4480 (2002)
  32. Synthesis of a polymer supported oxazolidine aldehyde for asymmetric chemistry
    A J Wills, Y Krishnan-Ghosh and S Balasubramanian
    J. Org. Chem. 67, 6646-6652 (2002)
  33. Enhanced cooperative binding of oligonucleotides to form DNA duplexes mediated by metal ion chelation
    I Horsey, Y Krishnan-Ghosh and S Balasubramanian
    Chem. Commun., 14, 1950-51 (2002)
  34. Solid phase synthesis of symmetrical 3,6-bispeptide-acridone conjugates
    S Ladame, R J Harrison, S Neidle and S Balasubramanian
    Org. Lett., 4, 2509-2512 (2002)
  35. Synthesis of diastereomerically pure 1,4,5-substituted-2-oxopiperazines on solid-phase
    N M Khan, M Cano and S Balasubramanian
    Tetrahedron Lett., 43, 2439-2443 (2002)
  36. Practical synthesis of a dithiane protected 3',5'-dialkyoxybenzoin photolabile safety-catch linker (BPSC) for solid phase organic synthesis
    M Cano, M Ladlow and S Balasubramanian
    J. Org. Chem., 67, 129-135 (2002)
  37. Studies on the chemical stability and functional group compatibility of the Benzoin Photolabile Safety-catch (BPSC) linker using an analytical construct
    M Cano, M Ladlow and S Balasubramanian
    J. Combinatorial Chemistry, 4, 44-48 (2002)
  38. Solid Phase Chemical Technologies for Combinatorial Chemistry
    S Balasubramanian
    J. Cell. Biochem. Suppl., 37, 28-33 (2001)
  39. Non-Arrhenius kinetics of a DNA Hairpin-Loop
    L Ying, M I Wallace, S Balasubramanian and D Klenerman
    Proc. Natl. Acad. Sci. USA, 98, 5584-5589 (2001)
  40. Probing DNA surface attachment and local environment using single molecule spectroscopy
    M A Osborne, C L Barnes, S Balasubramanian and D Klenerman
    J. Phys. Chem. B, 105, 3120-3126 (2001)
  41. Selection of Zinc Fingers that Bind Single-Stranded Telomeric DNA in the G-Quadruplex Conformation
    M Isalan, S D Patel, S Balasubramanian and Y Choo
    Biochemistry, 40, 830-836 (2001)
  42. Exploring a Benzyloxyaniline Linker Utilizing Ceric Ammonium Nitrate (CAN) as a Cleavage Reagent: Solid-Phase Synthesis of N-Unsubstituted Beta-Lactams and Secondary Amides
    K Gordon and S Balasubramanian
    Org. Lett., 3, 53-56 (2001)
  43. The Science of chemical discovery: probing the unknown with new technologies
    S Balasubramanian
    Drug Discovery Today, vol.5, 12, 533-534 (2000)
  44. FRET Fluctuation Spectroscopy: Exploring the Conformational Dynamics of a DNA Hairpin Loop
    M I Wallace, L Ying, S Balasubramanian and D Klenerman
    J. Phys. Chem. B, 104, 11551-11555 (2000)
  45. A stereoselective synthesis of 1,3,4-substituted -lactams from polymer-supported chiral oxazolidine aldehyde
    K Gordon, M Bolger, N Khan and S Balasubramanian
    Tetrahedron Lett., 41, 8621-8625 (2000)
  46. Strategies for the synthesis of fluorescently labelled PNA
    X Liu and S Balasubramanian
    Tetrahedron Lett., 41, 6153-6156 (2000)
  47. Single Molecule Analysis of DNA Immobilised on Microspheres
    M A Osborne, W S Furey, D Klenerman and S Balasubramanian
    Anal. Chem., 72, 3678-3681 (2000)
  48. Ratiometric analysis of single-molecule fluorescence resonance energy transfer using logical combinations of threshold criteria: A study of 12-mer DNA
    L Ying, M I Wallace, S Balasubramanian and D Klenerman
    J. Phys Chem B, 104, 5171-5178 (2000)
  49. Recent Developments in the Encoding and Deconvolution of Combinatorial Libraries
    C L Barnes and S Balasubramanian
    Current Opinion in Chemical Biology, 4, 346-350 (2000)
  50. Double Fluorescence Resonance Energy Transfer to Explore Multicomponent Binding Interactions: A Case Study of DNA Mismatches
    I Horsey, W S Furey, J G Harrison, M A Osborne and S Balasubramanian
    Chem. Commun., 12, 1043-1044 (2000)
  51. Solid Phase Preparation of Tertiary Amides and 1,2,4,5-Tetrasubstituted Imidazoles Using a Traceless Cleavage Strategy Based on Benzylic Acyl Ammonium Chloride Reactivity
    H B Lee and S Balasubramanian
    Org. Lett., 2, 323-326 (2000)

Top

pre-2000

  1. Screening for Oligonucleotide Binding Affinity by a Convenient Fluorescence Competition Assay
    
J G Harrison, X Liu and S Balasubramanian

    Nucleic Acids Research, 27 e14 (1999)
  2. Thermodynamic Melting Studies on Oligonucleotide-Peptide Conjugates
    
C Frier, J G Harrison and S Balasubramanian
    
Nucleosides and Nucleotides, 18 1477-1478 (1999)
  3. Solid Phase Synthesis: Designer Linkers for Combinatorial Chemistry
    
K Gordon and S Balasubramanian

    J. Chem. Tech. Biotech., 74, 835-851(1999)
  4. Recent Advances in Solid-Phase Chemical Methodologies
    
K Gordon and S Balasubramanian

    Current Opinion in Drug Discover and Development 2, 342-349 (1999)
  5. Exploring a Chemical Encoding Strategy for Combinatorial Synthesis using Friedels-Craft Alkylation

    R H Scott, C Barnes, U Gerhard and S Balasubramanian

    Chem Commun. 1331-1332 (1999)
  6. Studies on Dithiane Protected Benzoin Photolabile Safety Catch Linker for Solid Phase Synthesis
    
H B Lee and S Balasubramanian
    
J. Org. Chem., 64, 3454-3460 (1999); 64, 5728 (legend correction) (1999)
  7. Inhibition of Human Telomerase by PNA- Cationic Peptide Conjugates
    
J G Harrison, C Frier, R Laurant, K D Raney and S Balasubramanian

    Bioorg. Med. Chem. Lett., 9, 1273-1278 (1999)
  8. Progress in Chemical Encoding for Combinatorial Synthesis

    C Barnes, R H Scott and S Balasubramanian

    Recent Res. Devel. in Organic Chem. 2, 367-379 (1998)
  9. Synthesis and Hybridisation Properties of a Library of Oligonucleotide-Peptide Conjugates
    
J G Harrison and S Balasubramanian
    
Nucleic Acids Research, 26, 3136-3145 (1998)
  10. Optically Biased Diffusion of Single Molecules Studied by Confocal Fluorescence Microscopy

    M A Osbourne, S Balasubramanian, W S Furey and D Klenerman
    
J. Phys. Chem. B, 102, 3160-3167 (1998)
  11. Use of Fluorescence Resonance Energy Transfer to Investigate the Conformation of DNA Substrates Bound to the Klenow Fragment
    
W S Furey, C M Joyce, M A Osbourne, D Klenerman, J A Peliska and S Balasubramanian

    Biochemistry, 37, 2979-2990 (1998)
  12. A Combinatorial Approach to Identifying Protein Tyrosine Phosphatase Substrates from a Phosphotyrosine peptide Library

    Y W Cheung, C Abell and S Balasubramanian

    J. Am. Chem. Soc., 119, 9568-9569. (1997)
  13. Studies on the Synthesis, Characterisation and Reactivity of Aromatic Diboronic Acids
    
M H Todd, S Balasubramanian and C Abell

    Tetrahedron Lett., 38, 6781-6784 (1997)
  14. Synthesis of 2-Oxindole Derivatives via the Intramolecular Heck Reaction on Solid Support
    
V Arumugam, A Routledge, C Abell and S Balasubramanian

    Tetrahedron Lett., 38, 6473-6476 (1997)
  15. Properties of Fluorophores on Solid Phase Resins; Implications for Screening, Encoding and Reaction Monitoring
    
R H Scott and S Balasubramanian

    Bioorg. Med. Chem. Lett., 7, 1567-1572 (1997)
  16. A Convenient Synthetic Route to Oligonucleotide Conjugates
    
J G Harrison and S Balasubramanian

    Bioorg. Med. Chem. Lett., 7, 1041-1046 (1997)
  17. The Use of a Dithiane Protected Benzoin Photolabile Safety Catch Linker for Solid-Phase Synthesis
    
A Routledge, C Abell and S Balasubramanian
    
Tetrahedron Lett., 38, 1227-1230 (1997)
  18. An Investigation into Solid-Phase Radical Chemistry - Synthesis of Furan Rings

    A Routledge, C Abell and S Balasubramanian
    
SynLett, 61-62 (1997)
  19. Solid Phase Reductive Alkylation of Secondary Amines
    
N K Khan, V Arumugam and S Balasubramanian

    Tetrahedron Lett., 37, 4819-4822 (1996)
  20. Escherichia coli Chorismate Synthase Catalyses the Conversion of (6S)-6-fluoro-5-enolpyruvylshikimate-3-phosphate to 6-fluorochorismate

    S Bornemann, M K Ramjee, S Balasubramanian, C Abell, J R Coggins, D J Lowe and R N F Thorneley

    J. Biol. Chem., 270, 22811-22815 (1995)
  21. The Mechanism of Metal Independent Hydroxylation by Chromobacterium violaceum Phenylalanine Hydroxylase
    
R T Carr, S Balasubramanian, P Hawkins and S J Benkovic
    
Biochemistry, 34, 7525-7532 (1995)
  22. Escherichia coli Chorismate Synthase: A Deuterium Kinetic Isotope Effect Under Single Turnover and Steady State Conditions shows that a Flavin Intermediate forms before the C-(6proR)-H bond is cleaved
    
S Bornemann, S Balasubramanian, J R Coggins, C Abell, D J Lowe and R N F Thorneley
    
Biochem. J., 305, 707-710 (1995)
  23. Observation of a Secondary Tritium Isotope Effect in the Reaction Catalyzed by Neurospora Crassa Chorismate Synthase
    
S Balasubramanian, J R Coggins and C Abell

    Biochemistry, 34, 341-348 (1995)
  24. Recombinant HIV-1 Nucleocapsid Protein Accelerates HIV-1 Reverse Transcriptase Catalyzed DNA Strand Transfer Reactions and Modulates RNase H Activity

    J A Peliska, S Balasubramanian, D P Giedroc and S J Benkovic

    Biochemistry, 33, 13817-13823 (1994)
  25. Identification of Metal Ligands in Cu(II) Inhibited Chromobacterium violaceum Phenylalanine Hydroxylase by Electron Spin Echo Envelope Modulation Analysis of Histidine to Serine Mutations

    S Balasubramanian, R T Carr, C J Bender, J Peisach and S J Benkovic
    
Biochemistry, 33, 8532-8537 (1994)
  26. Studies on Escherichia coli Chorismate Synthase
    
S Borneman, M N Ramjee, D J Lowe, R N F Thorneley, J R Coggins, C Abell, S Balasubramanian, T R Hawkes, W W Nichols and G M Davies

    Flavins and Flavoproteins, (Ed. K. Yagi) 843-846. Walter de Gruyer, Berlin, New York (1994)
  27. Histidines 138 and 143 are Copper Binding Ligands in Chromobacterium violaceum Phenylalanine Hydroxylase
    
S Balasubramanian, R T Carr, C J Bender, J Peisach and S J Benkovic
    
Chemistry and Biology of Pteridines and Folates, Eds. J.E. Ayling, M.G. Nair, and C.M. Baugh 67-71 (1993)
  28. Reaction of (6R)-6-F-EPSP with Recombinant Escherichia coli Chorismate Synthase Generates a Stable Flavin Mononucleotide Semiquinone Radical
    
M N Ramjee, S Balasubramanian, C Abell, J R Coggins, G M Davies, T R Hawkes, D J Lowe and R N F Thorneley

    J. Am. Chem. Soc., 114, 3151-3153 (1992)
  29. Inhibition of Chorismate Synthase by (6R)- and (6S)-6-Fluoro-5-enolpyruvylshikimate 3-Phosphate

    S Balasubramanian, G M Davies, J R Coggins and C Abell

    J. Am. Chem. Soc., 113, 8945-8946 (1991)
  30. The Synthesis of (6R)-[6-2H]- and (6S)-[6-2H]5-Enolpyruvylshikimate 3-Phosphate
    
S Balasubramanian and C Abell

    Tetrahedron Lett., 32, 963-966 (1991)
  31. Observation of an Isotope Effect in the Chorismate Synthase Reaction
    
S Balasubramanian, C Abell and J R Coggins
    
J. Am. Chem. Soc., 112, 8581-8583 (1990)