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Centre for Experimental Biophysical Chemistry

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  • Currently displaying 1 - 20 of 987 publications
Selenium-silk microgels as antifungal and antibacterial agents
EG Wiita, Z Toprakcioglu, AK Jayaram, TPJ Knowles
– Nanoscale Horiz
(2024)
9,
609
Design of amyloidogenic peptide traps
DD Sahtoe, EA Andrzejewska, HL Han, E Rennella, MM Schneider, G Meisl, M Ahlrichs, J Decarreau, H Nguyen, A Kang, P Levine, M Lamb, X Li, AK Bera, LE Kay, TPJ Knowles, D Baker
– Nature Chemical Biology
(2024)
High-density volumetric super-resolution microscopy
S Daly, J Ferreira Fernandes, E Bruggeman, A Handa, R Peters, S Benaissa, B Zhang, JS Beckwith, EW Sanders, RR Sims, D Klenerman, SJ Davis, K O’Holleran, SF Lee
– Nature Communications
(2024)
15,
1940
High-density volumetric super-resolution microscopy.
S Daly, J Ferreira Fernandes, E Bruggeman, A Handa, R Peters, S Benaissa, B Zhang, JS Beckwith, EW Sanders, RR Sims, D Klenerman, SJ Davis, K O'Holleran, SF Lee
– Nat Commun
(2024)
15,
1940
A Relationship between the Structures and Neurotoxic Effects of Aβ Oligomers Stabilized by Different Metal Ions.
S Chia, RL Cataldi, FS Ruggeri, R Limbocker, I Condado-Morales, K Pisani, A Possenti, S Linse, TPJ Knowles, J Habchi, B Mannini, M Vendruscolo
– ACS Chem Neurosci
(2024)
15,
1125
Large-scale visualisation of α-synuclein oligomers in Parkinson’s disease brain tissue
R Andrews, B Fu, CE Toomey, JC Breiter, J Lachica, R Tian, JS Beckwith, L-M Needham, GJ Chant, C Loiseau, A Deconfin, K Baspin, PJ Magill, Z Jaunmuktane, OJ Freeman, BJM Taylor, J Hardy, T Lashley, M Ryten, M Vendruscolo, NW Wood, LE Weiss, S Gandhi, SF Lee
(2024)
Antibody agonists trigger immune receptor signaling through local exclusion of receptor-type protein tyrosine phosphatases
AH Lippert, C Paluch, M Gaglioni, MT Vuong, J McColl, E Jenkins, M Fellermeyer, J Clarke, S Sharma, S Moreira da Silva, B Akkaya, C Anzilotti, SH Morgan, CF Jessup, M Körbel, U Gileadi, J Leitner, R Knox, M Chirifu, J Huo, S Yu, N Ashman, Y Lui, I Wilkinson, KE Attfield, L Fugger, NJ Robertson, CJ Lynch, L Murray, P Steinberger, AM Santos, SF Lee, RJ Cornall, D Klenerman, SJ Davis
– Immunity
(2024)
57,
256
Cathepsin B Processing is Required for the in vivo Efficacy of Albumin-Drug Conjugates
B Bernardim, J Conde, T Hakala, JB Becher, M Canzano, AV Vasco, TPJ Knowles, J Cameron, GJL Bernardes
– Bioconjug Chem
(2024)
35,
132
Self-replication of Aβ42 aggregates occurs on small and isolated fibril sites.
S Curk, J Krausser, G Meisl, D Frenkel, S Linse, TCT Michaels, TPJ Knowles, A Šarić
– Proceedings of the National Academy of Sciences of the United States of America
(2024)
121,
e2220075121
Maturation-dependent changes in the size, structure and seeding capacity of Aβ42 amyloid fibrils.
A Miller, S Chia, E Klimont, TPJ Knowles, M Vendruscolo, FS Ruggeri
– Communications biology
(2024)
7,
153
Temperature-induced changes in protein interactions control RNA recruitment to G3BP1 condensates
CM Fischer, H Ausserwöger, T Sneideris, D Qian, R Scrutton, S Qamar, P St George-Hyslop, TPJ Knowles
(2024)
Novel methods to study amyloid oligomers
LO Pascual, EA Andrzejewska, T Pálmadóttir, TP Knowles, S Linse
– Biophysical Journal
(2024)
123,
41a
Thermodynamics of temperature modulation in biomolecular phase separation
CM Fischer, H Ausserwöger, T Sneideris, D Qian, R Scrutton, S Qamar, P St George-Hyslop, TP Knowles
– Biophysical Journal
(2024)
123,
495a
Molecular chaperones and their role in amyloid formation
MM Schneider, A Bracher, EA Andrzejewska, G Krainer, L-U Lin, R Riek, U Hartl, TPJ Knowles
– Biophysical Journal
(2024)
123,
301a
The Alzheimer’s Aβ peptide forms biomolecular condensates that trigger amyloid aggregation
Š Greta, AG Díaz, SD Adhikari, J Wei, T Michaels, T Šneideris, S Linse, M Vendruscolo, K Garai, TPJ Knowles
(2024)
Microfluidic antibody profiling after repeated SARS-CoV-2 vaccination links antibody affinity and concentration to impaired immunity and variant escape in patients on anti-CD20 therapy
A Priddey, MXH Chen-Xu, DJ Cooper, S MacMillan, G Meisl, CK Xu, M Hosmillo, IG Goodfellow, R Kollyfas, R Doffinger, JR Bradley, II Mohorianu, R Jones, TPJ Knowles, R Smith, V Kosmoliaptsis
– Frontiers in Immunology
(2024)
14,
1296148
Aggregation of the Amyloid-β Peptide (Aβ40) within Condensates Generated through Liquid-Liquid Phase Separation
O Morris, Z Toprakcioglu, A Röntgen, M Cali, T Knowles, M Vendruscolo
(2023)
Nanoscale profiling of evolving intermolecular interactions in ageing FUS condensates
A Miller, Z Toprakcioglu, S Qamar, P St. George-Hyslop, S Ruggeri, T Knowles, M Vendruscolo
(2023)
Monoclonal antibodies targeting cytotoxic α-synuclein oligomers: molecular properties and diagnostic potential
D Otzen, J Nielsen, J Lauritsen, J Pedersen, J Nowak, M Bendtsen, G Kleijwegt, M Schneider, G Krainer, T Knowles, L Goksøyr, P Khalifé, S Kaalund, S Aznar, M Kjærgaard, M Nielsen, F Sander, M Romero-Ramos
(2023)
RASP: Optimal single fluorescent puncta detection in complex cellular backgrounds
B Fu, EE Brock, R Andrews, JC Breiter, R Tian, CE Toomey, J Lachica, T Lashley, M Ryten, NW Wood, M Vendruscolo, S Gandhi, LE Weiss, JS Beckwith, SF Lee
(2023)