Waters’ Synapt G2-Si Quadrupole-Ion mobility-TOF hybrid instrument serves a broad range of applications by providing the most extensive range of targeted data acquisition. The instrument incorporates the newest technologies in the area of ion optics and ion mobility separation, with interchangeable universal ion source architecture, allowing the use of nanoESI and ESI ion sources on the same instrument. The system is also be equipped with two methods of gas-phase fragmentation - Collision Induced Dissociation (CID) and Electron Transfer Dissociation (ETD). Hydrogen-deuterium exchange (HDX) experiments can be carried out to probe protein structures and interactions using the first commercially available automated system. Samples can either be run via the service or you can be trained to run your own. Contact a member of the Mass Spec team to arrange training.